GAO Jian-de, ZHU Xiao-yu, SONG Kai-rong, et al. Effect of Five Kinds of Pharmaceutical Excipients on Moisture Absorption and Formability of Codonopsis Radix Granules[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 13-17.
DOI:
GAO Jian-de, ZHU Xiao-yu, SONG Kai-rong, et al. Effect of Five Kinds of Pharmaceutical Excipients on Moisture Absorption and Formability of Codonopsis Radix Granules[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 13-17. DOI: 10.13422/j.cnki.syfjx.2017230013.
Effect of Five Kinds of Pharmaceutical Excipients on Moisture Absorption and Formability of Codonopsis Radix Granules
Objective: To study on the effect of several medicinal excipients
such as microcrystalline cellulose (MCC)
soluble starch (ST)
dextrin (DE)
maltodextrin (MA) and sodium carboxymethyl starch (CMS-Na)
on the moisture absorption and formability of Codonopsis Radix granules. Method: A single excipient or two kinds of excipients with different ratio were mixed with Codonopsis Radix extract by 1:1
the moisture absorption kinetics of Codonopsis Radix granules was fitted by Higuch equation
Weibull distribution and unitary quadratic curve equation model
respectively.The best prescription of this granules was evaluated by the moisture absorption
forming and dissolubility. Result: Optimum molding materials was mixture of MCC and DE
ratio of Codonopsis Radix extract-MCC-DE was 3:2:1
Codonopsis Radix granules could be totally dissolved in 2 min with forming rate of 85.41%
equilibrium moisture content of this granules within 48 h was 6.28%. Conclusion: The optimum process is stable and feasible
it can effectively reduce the hygroscopicity of Codonopsis Radix granules.
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