Objective: To observe the effect of Fushen granules on the peritoneal ultrafiltration function

glyoxalase-1 (Glo-1) and advanced glycation end products (AGEs) in rats with peritoneal dialysis. Method: The chronic renal failure peritoneal dialysis rat model was induced through 5/6 nephrectomy. After successful modeling

the SD rats were randomly divided into 1.5% PD model group; 1.5% PD+Fushen granules intervention group; 4.25% PD model group; and 4.25% PD+Fushen granules intervention group (group E)

with 17 rats in each group; the control group was also set up

with 15 rats. After 4 weeks

the rats were put to death

and their peritoneal tissues and serum were collected to calculate the peritoneal ultrafiltration volume; Western blot was used to detect the rat peritoneal organization Glo-1 protein expression. And enzyme-linked immunoassay (ELISA) was used to detect the content of serum AGEs. Result: Peritoneal ultrafiltration and serum AGEs content in Fushen granules intervention group were lower than dialysis model group of the same concentration

with statistically significant differences (P<0.05

P<0.01). Compared with the control group

Glo-1 protein content increased in the model group

with statistically significant differences (P<0.05). Glo-1 protein expression in group B was higher than that in group C

but with on statistically significant difference. Compared with group E

Glo-1 protein expression was significantly elevated

with statistically significant differences (P<0.05). Conclusion: Fushen granules can regulate the expression of Glo-1 and reduce the accumulation of serum AGEs

so as to protect the residual kidney function and delay peritoneal filtration and peritoneal fibrosis.