Effect of Shengui Yixin Decoction on Toll-like Receptors 4/Nuclear Factor Kappa B in Patients with Chronic Heart Failure

FENG Qin-tao; YANG Jing; ZHANG Yan; LYU Shang-zeng; MIAO Hua-wei

doi:10.13422/j.cnki.syfjx.2017230146

您当前的位置：

首页 >

文章列表页 >

Effect of Shengui Yixin Decoction on Toll-like Receptors 4/Nuclear Factor Kappa B in Patients with Chronic Heart Failure

更新时间：2024-01-04

- Effect of Shengui Yixin Decoction on Toll-like Receptors 4/Nuclear Factor Kappa B in Patients with Chronic Heart Failure
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 23, Pages: 146-151(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017230146
  CLC： R285.6
- Published：2017
- 稿件说明：
移动端阅览
FENG Qin-tao, YANG Jing, ZHANG Yan, et al. Effect of Shengui Yixin Decoction on Toll-like Receptors 4/Nuclear Factor Kappa B in Patients with Chronic Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 146-151.
DOI：

FENG Qin-tao, YANG Jing, ZHANG Yan, et al. Effect of Shengui Yixin Decoction on Toll-like Receptors 4/Nuclear Factor Kappa B in Patients with Chronic Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 146-151. DOI： 10.13422/j.cnki.syfjx.2017230146.

摘要

目的：观察参桂益心汤对慢性心力衰竭患者外周血单核细胞Toll样受体4/核转录因子-κB（TLR4/NF-κB）信号通路的影响。方法：124例慢性心力衰竭患者按随机数字表法分为对照组（50例）和治疗组（74例），对照组给予西医常规药物治疗，治疗组在对照组基础上加用参桂益心汤，每日1剂，疗程4周。比较两组治疗前后心功能，包括心率（HR），左室射血分数（LVEF），左室舒张末期内径（LVDD），6 min步行实验距离（6 mWT）；测定两组治疗前后外周血单核细胞TLR4，NF-κB及肿瘤坏死因子-α（TNF-α），白细胞介素-6（IL-6），白细胞介素-1β（IL-1β）mRNA和蛋白表达；患者出院后随访6~18个月，观察两组再住院率、病死率及再住院次数。结果：与对照组比较，治疗组总有效率明显升高（P<0.05）；与对照组比较，治疗组HR，LVDD明显降低，LVEF，6 mWT明显增加（P<0.05）；治疗组较对照组TLR4，NF-κB，TNF-α，IL-6，IL-1β mRNA和蛋白表达明显降低（P<0.05）；二组患者均较治疗前好转（P<0.05）。治疗组再住院率、病死率及再住院次数较对照组明显降低（P<0.05）。结论：参桂益心汤能够抑制慢性心力衰竭患者外周血单核细胞TLR4/NF-κB信号通路，抑制炎症，改善患者心功能。

Abstract

Objective: To observe the effect of Shengui Yixin decoction on plasma monocyte Toll-like receptors 4/nuclear factor kappa B (TLR4/NF-κB) signal pathway in patients with chronic heart failure. Method: A total of 124 patients with chronic heart failure were divided into control group (50 cases) and treatment group (74 cases) by random number table. The control group was given routine western medicine therapy. The treatment group was given Shengui Yixin decoction for 4 weeks

1 agent/day in addition to the therapy of control group. Heart rate (HR)

left ventricular ejection fraction (LVEF)

left ventricular end diastolic diameter (LVDD)

and 6 minute walking distance (6 mWT)

TLR4

NF-κB

tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6)

interleukin1β (IL-1β) mRNA and protein expressions in two groups before and after treatment were observed. Patients were followed up for 6 to 18 months after discharge. Rate of rehospitalization

fatality and the number of rehospitalization were compared between two groups. Result: Compared with control group

the total efficiency of treatment group increased significantly (P<0.05). After the treatment

LVDD

TLR4

NF-κB

TNF-α

IL-6 and IL-1β mRNA and protein expressions of treatment group were significantly lower than those of control group; LVEF

6 mWT of treatment group were significantly higher than those of control group (P<0.05). both groups showed alleviations compared with before hospitalization (P<0.05). Rehospitalization rate

death rate and frequency of rehospitalization of treatment group were lower than those of control group (P<0.05). Conclusion: Shengui Yixin decoction in treating patients with chronic heart failure can significantly inhibit TLR4/NF-κB signal pathway and inflammation and improve the patients' cardiac function.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Shengui Yixin Decoction on Patients with Chronic Heart Failure and Its Effect on Cardiac Ultrasound Index

Analysis of Animal Model of Chronic Heart Failure Based on Combination of Diseases and Syndromes of Traditional Chinese Medicine and Western Medicine

Protective Effect of Shengxiantang on Myocardial Microvascular Injury in Rats with Chronic Heart Failure

Construction and Verification of Prediction Model of Qi Deficiency and Blood Stasis Syndrome in Chronic Heart Failure

Effect of Yiqi Wenyang Huoxue Lishui Components on Cardiac Function and Mitochondrial Energy Metabolism in CHF Rats

Related Author

FENG Qing-tao

ZHANG Xueyan

ZHANG Kexin

YU You

ZHANG Huan

DUAN Yingzhu

YU Rui

GAO Hui

Related Institution

The Second Affiliated Hospital of Liaoning University of Chinese Medicine

Liaoning University of Chinese Medicine

Hebei Higher Education Institute Applied Technology Research Center for TCM Development and Industrialization

Hebei Technology Innovation Center for TCM Formula Preparations

Hebei Provincial Hospital of Traditional Chinese Medicine（TCM）

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰