TAO Na, LI Ya-lan, XIANG Yi. Efficacy of Qiju Dihuangwan on Dry Eye in Patients After Cataract Operation and Its Effect on Scores of BUT, SIT and FL[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 166-170.
DOI:
TAO Na, LI Ya-lan, XIANG Yi. Efficacy of Qiju Dihuangwan on Dry Eye in Patients After Cataract Operation and Its Effect on Scores of BUT, SIT and FL[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 166-170. DOI: 10.13422/j.cnki.syfjx.2017230166.
Efficacy of Qiju Dihuangwan on Dry Eye in Patients After Cataract Operation and Its Effect on Scores of BUT, SIT and FL
目的:探讨杞菊地黄丸对白内障术后干眼症患者疗效、泪膜破裂时间(tear breakup time,BUT),基础泪液分泌实验(schirmer I test,SIT)及角膜荧光素染色(fluorescent test,FL)的影响。方法:研究对象选自2016年2月—2017年1月华中科技大学同济医学院附属武汉中心医院收治的116例白内障术后干眼症患者,采取随机数字表将其分成两组,其中观察组58例(64眼),对照组58例(66眼)。两组患者均采用人工泪液治疗,观察组联合给予杞菊地黄丸治疗,比较两组临床疗效及治疗前后BUT,SIT,FL评分及症状评分变化情况。结果:观察组治疗总有效率为93.75%,相对于对照组的77.27%显著上升(P<0.01)。两组治疗后2周,1个月,3个月BUT均较治疗前显著延长(P<0.01),观察组治疗后各时点延长更明显(P<0.05)。两组治疗后2周,1个月,3个月SIT均较治疗前显著增加(P<0.01),观察组治疗后各时点增加幅度更明显(P<0.05)。两组治疗后2周,1个月,3个月FL评分均较治疗前显著降低(P<0.01),观察组治疗后各时点下降更显著(P<0.01)。两组治疗后2周,1个月,3个月干眼症状评分均较治疗前显著下降(P<0.01),观察组治疗后各时点下降更显著(P<0.01)。结论:杞菊地黄丸治疗白内障术后干眼症可有效提高泪膜稳定性,改善视觉功能,疗效确切。
Abstract
Objective: To observe the efficacy of Qiju Dihuangwan on dry eye in patients after cataract operation and its effect on scores of tear breakup time (BUT)
schirmer I test (SIT)
and fluorescent test (FL). Method: The subjects of this study were selected from 116 cases of dry eye in patients after cataract surgery treated at our hospital from February 2016 to January 2017
and divided into two groups by means of random number table
with 58 cases (64 eyes) in observation group and 58 cases (66 eyes) in control group. Both groups were given artificial tears
and observation group was additionally given Qiju Dihuangwan. The clinical effects and the changes in BUT
SIT
FL and dry eye symptom scores of two groups were compared. Result: The overall effective rate of the observation group was 93.75%
which was significantly higher than 77.27% of control group (P<0.01). Two 2 weeks
1 month
3 months later after operation
BUT in both groups was obviously prolonged (P<0.01)
while the increase at each time point in observation group was more evident (P<0.05). Two 2 weeks
1 month
3 months later after operation
SIL in both groups was increased markedly (P<0.01)
while the increase at each time point in observation group was more significant (P<0.05). Two 2 weeks
1 month
3 months later after operation
FL in two groups decreased (P<0.01)
while the decrease was more significant in observation group (P<0.01). Two 2 weeks
1 month
3 months later after operation
the symptom scores also decreased remarkably (P<0.01)
while the decrease in observation group was more significant (P<0.01). Conclusion: In the treatment of dry eye in patients after cataract surgery
Qiju Dihuangwan has a curative effect in improving the stability of tear film and the visual function.
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