Objective: To observe the effect of oral Huoxue Shengji decoction and foot massage on early diabetic foot (DF) with Qi and Yin deficiency and syndrome of obstruction of choroid

and investigate its action mechanism from vascular endothelial function

oxidative stress and inflammation reaction. Method: One hundred and ten patients with DF were randomly divided into control group and observation group by random number table

55 cases in each group. Patients in control group got mecobalamin injection at the place of protective measures

0.5 mg/time

3 times/week by intramuscular injection. Aspirin enteric-coated tablets

100 mg/time

1 time/day. Based on the treatment in control group

patients in observation group added oral Huoxue Shengji decoction and foot massage. The treatment course was 12 weeks in both groups. Peroneal nerve

motor nerve conduction velocity (MNCV)

sensory nerve conduction velocity (SNCV)

and ankle brachial index (ABI) were detected. Scores of Qi and Yin deficiency

syndrome of obstruction of choroid and toronto clinical neuropathy (TCSS) were graded. And levels of nitric oxide (NO)

visfatin and endothelin-1 (ET-1)

malondialdehyde (MDA)

superoxide dismutase (SOD)

intercellular adhesion molecule-1 (ICAM-1)

C-reactive protein (CRP) and interleukin 6 (IL-6) were detected. Result: The total effective rate was 84.% in observation group

higher than 66.67% in control group (χ2=4.072

P<0.05). Peroneal nerve

motor nerve conduction velocity (MNCV) and (SNCV) in observation group were all faster than those in control group (P<0.01). Dimensional scores of TCSS scale and the total score in observation group were lower than those in control group. After treatment

ABI level and ascending range in observation group were higher than those in control group (P<0.01). Scores of Qi and Yin deficiency and closed choroid obstruction in observation group were lower than those in control group

and degree of declining in observation group was greater than that in observation group (P<0.01). Levels of visfatin

ET-1

MDA

ICAM-1

CRP and IL-6 in observation group were lower than those in control group (P<0.01)

and levels of NO and SOD were higher than those in control group (P<0.01). Conclusion: Oral Huoxue Shengji decoction and foot massage for early diabetic foot can improve peripheral vascular disease and neuropathy in patients

reduce clinical symptoms and signs

and the effect was better than the simple western medicine treatment. In addition

it can ameliorate the condition by regulating vascular endothelial function

reducing oxidative stress and inflammatory response.