Shexiang Tongxin Dropping Pills Combined with Trimetazidine Hydrochloride on Ischemic Heart Failure with Syndrome of Qi Deficiency and Stasis on Inflammatory Factors

WU Gang; SONG Yu-hua; HU Li-qun

doi:10.13422/j.cnki.syfjx.2017230188

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Shexiang Tongxin Dropping Pills Combined with Trimetazidine Hydrochloride on Ischemic Heart Failure with Syndrome of Qi Deficiency and Stasis on Inflammatory Factors

更新时间：2024-01-04

- Shexiang Tongxin Dropping Pills Combined with Trimetazidine Hydrochloride on Ischemic Heart Failure with Syndrome of Qi Deficiency and Stasis on Inflammatory Factors
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 23, Pages: 188-193(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017230188
  CLC： R541.6
- Published：2017
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WU Gang, SONG Yu-hua, HU Li-qun. Shexiang Tongxin Dropping Pills Combined with Trimetazidine Hydrochloride on Ischemic Heart Failure with Syndrome of Qi Deficiency and Stasis on Inflammatory Factors[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 188-193.
DOI：

WU Gang, SONG Yu-hua, HU Li-qun. Shexiang Tongxin Dropping Pills Combined with Trimetazidine Hydrochloride on Ischemic Heart Failure with Syndrome of Qi Deficiency and Stasis on Inflammatory Factors[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 188-193. DOI： 10.13422/j.cnki.syfjx.2017230188.

摘要

目的：探讨麝香通心滴丸联合盐酸曲美他嗪治疗气虚血瘀证缺血性心力衰竭（IHF）的临床疗效及对患者炎症因子的影响。方法：将112例IHF患者采用随机按数字表法分为对照组和研究组各56例。对照组给予盐酸曲美他嗪片治疗，3次/d，1片/次。研究组在对照组治疗的基础上加用麝香通心滴丸，2丸/次，3次/d。两组患者均连续治疗12周。比较两组患者左室心肌质量指数（LVMI），平均室壁应力（MWS），血浆B型脑利钠肽（NT-Pro BNP），气虚血瘀证症状体征积分、心率变异性（HRV）水平及临床疗效。检测两组患者血清中S100钙结合蛋白A8/A9复合物（S100A8/A9），核转录因子（NF）-κB，晚期糖基化终末产物受体（RAGE）水平。结果：治疗后研究组患者的MWS，LVMI，NT-Pro BNP和气虚血瘀证症状（心悸、气短、胸痛、下肢水肿、面色晦暗）评分均明显低于对照组（P<0.01）。研究组患者的临床总有效率为94.83%，明显高于对照组79.31%（P<0.05）；研究组治疗后正常R-R间期标准差（SDNN），正常R-R间期平均值标准差（SDANN），相邻RR间期差值的均方根（RMSSD），相邻正常R-R间期差值>50 ms心搏数占分析心搏数总数的百分比（PNN50）均高于对照组（P<0.01）；研究组治疗后血清中S100A8/A9，NF-κB，RAGE水平均低于对照组，比较差异有统计学意义（P<0.01）。结论：麝香通心滴丸联合曲美他嗪治疗IHF临床疗效显著，且可降低炎症因子S100A8/A9，NF-κB，RAGE水平。

Abstract

Objective: To investigate the clinical efficacy of Shexiang Tongxin dropping pills combined with trimetazidine in treating ischemic heart failure(IHF) and its effects on inflammatory factors. Method: One hundred and twelve IHF cases were randomly divided into control group and research group with 56 cases of each group. The patients in control group were given with trimetazidine

tid and 1 tablet/time. Based on the treatment in control group

the patients in research group were also given with Shexiang Tongxin dropping pills

2 pills/time and tid. The treatment course was 12 weeks in both groups. Left ventricular mass index (LVMI)

mean wall stress (MWS)

B-type natriuretic peptide (NT-Pro BNP)

symptom scores of syndrome of deficiency of heart Qi and blood stasis

level of heart rate variability (HRV)

and clinical efficacy were compared between two groups. The levels of S100 calcium binding protein A8/A9 complex (S100A8/A9)

nuclear transcription factor (NF)-κB

and receptor for advanced glycation end products (RAGE) were detected in both groups. Result: After treatment

MWS

LVMI

NT-Pro BNP

and symptom score of syndrome of deficiency of heart Qi and blood stasis in research group were obviously lower than those in control group (P<0.01). The total effective rate was 94.83% in research group

superior to 79.31% in control group (P<0.05). Normal R-R interval standard deviation (SDNN)

normal R-R interval mean standard deviation (SDANN)

root mean square difference value of adjacent R-R intervals (RMSSD)

adjacent normal R-R interval difference >50 ms beat number accounted for the total number of percentage of stroke (PNN50) were higher than the control group (P<0.01). And the levels of S100A8/A9

NF-κB

and RAGE in serum of research group were significantly lower than those of control group (P<0.01). Conclusion: Shexiang Tongxin dropping pills combined with trimetazidine had significant clinical efficacy in treating IHF

and can inhibit levels of inflammatory factor such as S100A8/A9

NF-κB

and RAGE.

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