Clinical Observation of Wuwei Xiaoke Decoction in Treatment of Type 2 Diabetes with Qi and Yin Deficiency

SHAN Liang-liang; DENG Xiao-min; GUO Chao-feng; LIU Ke; MEI Xiao-ping; XIE Jun-yan; YE Yuan-yuan

doi:10.13422/j.cnki.syfjx.2017240170

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Clinical Observation of Wuwei Xiaoke Decoction in Treatment of Type 2 Diabetes with Qi and Yin Deficiency

更新时间：2024-01-04

- Clinical Observation of Wuwei Xiaoke Decoction in Treatment of Type 2 Diabetes with Qi and Yin Deficiency
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 24, Pages: 170-174(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017240170
  CLC： R259
- Published：2017
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SHAN Liang-liang, DENG Xiao-min, GUO Chao-feng, et al. Clinical Observation of Wuwei Xiaoke Decoction in Treatment of Type 2 Diabetes with Qi and Yin Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(24): 170-174.
DOI：

SHAN Liang-liang, DENG Xiao-min, GUO Chao-feng, et al. Clinical Observation of Wuwei Xiaoke Decoction in Treatment of Type 2 Diabetes with Qi and Yin Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(24): 170-174. DOI： 10.13422/j.cnki.syfjx.2017240170.

摘要

目的：观察五味消渴方治疗2型糖尿病气阴两虚证的临床疗效，并探讨其作用机制。方法：选取128例2型糖尿病气阴两虚证患者，随机分为治疗组（64例）和对照组（64例），治疗组采用五味消渴方+基础治疗，对照组采用安慰剂+基础治疗，观察治疗前后患者症状、体征变化，检测空腹血糖（FBG），餐后2 h血糖（P2 hBG），糖化血红蛋白（HbA1c），空腹血清胰岛素（FINS），安全性指标（血、尿、便常规，肝、肾功能），计算胰岛素抵抗指数（HOMA-IR），中医证候评分。结果：两组患者分配均衡，基线状况良好，可比性强。中医证候方面，两组患者口渴喜饮、多食易饥、气短懒言、倦怠乏力、心悸失眠、五心烦热、舌红少津、脉细数无力均明显改善，治疗组优于对照组（P<0.05）；治疗组和对照组中医疗效总有效率分别为93.55%，76.19%，治疗组优于对照组（P<0.05）；两组患者治疗后FBG，P2 hBG，HbA1c，FINS，HOMA-IR均较治疗前改善，治疗组改善更明显（P<0.05）。结论：五味消渴方治疗2型糖尿病气阴两虚证疗效显著且安全，值得推广应用。

Abstract

Objective: To observe the effect of Wuwei Xiaoke decoction in treatment of type 2 diabetes with Qi and Yin deficiency. Method: A total of 128 patients with type 2 diabetes were selected and randomly divided into two groups:treatment group (64 cases) and control group (64 cases). Two groups were both treated with the basic therapy; the treatment group was additionally given Wuwei Xiaoke decoction

and control group was additionally given placebo. Clinical symptoms

sign changes

fasting blood glucose (FBG)

postprandial 2 h blood sugar (P2 hBG)

glycosylated hemoglobin (HbA1c)

fasting insulin level (FINS)

insulin resistance index (HOMA-IR)

traditional Chinese medicine (TCM) syndrome score of two groups were observed after treatment. Result: Two groups were evenly distributed

with a good baseline status and strong comparability. In the aspect of TCM syndrome scores

treatment group was significantly better than control group in the alleviation of clinical symptoms (P<0.05). The total clinical effective rate was 93.55% in treatment group was significantly higher than control group (P<0.05). After treatment

two groups showed alleviations in FBG and P2 hBG

HbA1c

FINS and HOMA-IR

particularly the treatment (P<0.05). Conclusion: Wuwei Xiaoke decoction has a significant efficacy and safety in treating type 2 diabetes with Qi and Yin deficiency syndrome

and thus is worth clinical popularization.

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