Research Advances in Protective Effect of Water-soluble Ingredients in Salviae Miltiorrhizae Radix et Rhizoma on Myocardial Ischemia and Reperfusion Injury
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Research Advances in Protective Effect of Water-soluble Ingredients in Salviae Miltiorrhizae Radix et Rhizoma on Myocardial Ischemia and Reperfusion Injury
Chinese Journal of Experimental Traditional Medical FormulaeVol. 23, Issue 24, Pages: 217-223(2017)
QI Tian-tian, BAO Yi-min, LIU Ai-hua. Research Advances in Protective Effect of Water-soluble Ingredients in Salviae Miltiorrhizae Radix et Rhizoma on Myocardial Ischemia and Reperfusion Injury[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(24): 217-223.
DOI:
QI Tian-tian, BAO Yi-min, LIU Ai-hua. Research Advances in Protective Effect of Water-soluble Ingredients in Salviae Miltiorrhizae Radix et Rhizoma on Myocardial Ischemia and Reperfusion Injury[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(24): 217-223. DOI: 10.13422/j.cnki.syfjx.2017240217.
Research Advances in Protective Effect of Water-soluble Ingredients in Salviae Miltiorrhizae Radix et Rhizoma on Myocardial Ischemia and Reperfusion Injury
Myocardial ischemia occurs when blood flow to heart is reduced or the myocardial oxygen demand is more than the maximum blood supply
resulting in changes in myocardial metabolism
function
and structure. Reperfusion after ischemia leads to cardiac functional damage
arrhythmias
and myocardial cell necrosis
known as ischemia/reperfusion injury. Its pathophysiology is complex
involving coronary artery stenosis
endothelial injury
platelet aggregation
energy metabolism disorder
oxidative stress
inflammation response
apoptosis
calcium overload and autophagy
forming a complex regulatory network. The current clinical medicines for myocardial ischemia and reperfusion mainly include antiplatelet drugs
beta blockers
calcium channel blockers
statins
RAS blockers
nitrates and thrombolytic therapy etc.Although there are many kinds of drugs mentioned above
the control effect is limited because of the single target of modern western medicine and many adverse reactions. With multiple targets and components
Salviae Miltiorrhizae Radix et Rhizoma
the main medicine for activating blood circulation and removing blood stasis
has been widely used in the treatment of cardiovascular disease
especially for the prevention and treatment of myocardial ischemic diseases. The water-soluble ingredient is acknowledged as the important active ingredient in treating cardiovascular diseases. The effect and mechanism of main water-soluble components (tanshinol
salvianolic acid A and salvianolic acid B) were compared in this paper to provide a theoretical basis for the clinical application of Salviae Miltiorrhizae Radix et Rhizoma.
Protective Effect of Shenlou Shuangxin Pills on Myocardial Ischemia Reperfusion Injury in Rats
Effect of Slicing Angle and Initial Water Content on Water Migration and Effective Ingredient Content in Drying Process of Salviae Miltiorrhizae Radix et Rhizoma
Pharmacological Effects and Mechanisms of Salviae Miltiorrhizae Radix et Rhizoma and Its Active Components in Treating Depression: A Review
Wendantang Regulates Energy Metabolism in Treatment of Myocardial Ischemia via SIRT3/PGC-1α Pathway
Active Components of Salviae Miltiorrhizae Radix et Rhizoma and Its Compound in Treatment of Nervous System Diseases: A Review
Related Author
ZHANG Ying-ying
GUO Hao
WANG Jie
GAO Jia-liang
SUN Jian-ning
YANG Guohong
ZHOU Bingqian
LU Heng
Related Institution
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
School of Pharmacy,Shandong Analysis and Test Center,Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province,Key Laboratory for Natural Active Pharmaceutical Constituents Research in Universities of Shandong Province, Qilu University of Technology(Shandong Academy of Sciences)
Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Academy of Chinese Medical Sciences,Henan University of Chinese Medicine
Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine