Depression is one kind of mental diseases and endangers human health seriously. Until now

Drug therapy has been the main treatment of depression. At present

most commonly-prescribed antidepressants are chemically synthesized

and most of which are monoamine neurotransmitters modulators. These drugs have many disadvantages

such as remarkable side effects

slow onset

expensive prices and poor treatment outcome. The traditional Chinese medicine(TCM) has a long history in treating depression

thus providing an alternative to antidepressants with better efficacy and less side effects.Chinese herbal compounds which have antidepressant effects

could be classified by mechanism as follows-relieving the depressed liver

calming the mind by nourishing the heart

regulating vital energy and dispelling phlegm

invigorating blood circulation to dissipate blood stasis. According to the source of TCM decoction pieces

single herbs and active ingredients can be divided into the following catagories-tonics

regulating Qi and promoting the circulation of blood

tranquilization and calming liver wind

clearing heat and removing dampness

relieving exterior syndrome and cough. The new research results and achievements of antidepressant pharmacological research will exert a profound impact on the idea of traditional syndrome differentiation and treatment as well as the habits in medicine employment. In this paper

anatomical structure and biochemical indicators are briefly discussed

and then TCM which have antidepressant effects

in recent years are reviewed. This review aims to provide reference to the research and development of herbal antidepressants.