Mechanism of Peitu Shengjin Decoction for Airway Remodeling in Patients with Chronic Obstructive Pulmonary Disease at Stationary Phase

HUANG Shao-jun; FU Ru-mei

doi:10.13422/j.cnki.syfjx.2018010174

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Mechanism of Peitu Shengjin Decoction for Airway Remodeling in Patients with Chronic Obstructive Pulmonary Disease at Stationary Phase

更新时间：2024-01-04

- Mechanism of Peitu Shengjin Decoction for Airway Remodeling in Patients with Chronic Obstructive Pulmonary Disease at Stationary Phase
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 1, Pages: 174-179(2018)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2018010174
  CLC： R259
- Published：2018
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HUANG Shao-jun, FU Ru-mei. Mechanism of Peitu Shengjin Decoction for Airway Remodeling in Patients with Chronic Obstructive Pulmonary Disease at Stationary Phase[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(1): 174-179.
DOI：

HUANG Shao-jun, FU Ru-mei. Mechanism of Peitu Shengjin Decoction for Airway Remodeling in Patients with Chronic Obstructive Pulmonary Disease at Stationary Phase[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(1): 174-179. DOI： 10.13422/j.cnki.syfjx.2018010174.

摘要

目的：探讨培土生金方治疗慢性阻塞性肺疾病（COPD）稳定期肺脾气虚证兼血瘀证的临床疗效及对气道重塑机制的研究。方法：选择160例符合要求的患者，根据就诊先后，采用随机按数字表法分为对照组和观察组各80例。对照组给予噻托溴铵粉吸入剂治疗。观察组噻托溴铵粉吸入剂使用同对照组，并给予培土生金方。两组疗程均为4个月。进行治疗前后肺功能检查，记录用力肺活量（FVC），第1秒用力呼气容积（FEV1），FEV1占预计值百分比（FEV1%）；进行治疗后中医证候量表和呼吸困难指数（MMRC）评分；检测治疗前后白细胞介素-6（IL-6），IL-8，肿瘤坏死因子-α（TNF-α），转化生长因子-β1（TGF-β1），血管内皮生长因子（VEGF），基质金属蛋白酶（MMP-2），MMP-9和基质金属蛋白酶组织抑制剂（TIMP-1）水平。结果：观察组患者临床疗效总有效率为89.33%，对照组为73.61%，观察组高于对照组（χ2=6.056，P<0.05）；治疗后观察组中医证候主要症状评分、总积分，MMRC评分均低于对照组（P<0.01）；治疗后观察组FEV1%较治疗前增加，并高于治疗后对照组水平（P<0.05）；治疗后观察组患者血清IL-6，IL-8，TNF-α水平均低于对照组（P<0.01）；治疗后观察组患者血清TGF-β1，VEGF，MMP-2，MMP-9，TIMP-1水平均低于对照组（P<0.01）。结论：培土生金方治疗COPD肺脾气虚证兼血瘀证患者，能缓解临床症状、提高肺功能的作用，并能抑制炎症因子反应，调节生长因子、蛋白酶-抗蛋白酶的失衡，减轻患者气道重塑作用。

Abstract

Objective:To discuss the clinical effect of Peitu Shengjin decoction for chronic obstructive pulmonary disease (COPD

Qi deficiency of lung and spleen) at stationary phase and investigate the mechanism of airway remodeling. Method:One hundred and sixty patients were randomly divided into control group 80 cases and observation group 80 cases by random number table. Patients in control group received tiotropium bromide powder for inhalation. Based on the treatment in control group

patients in observation group added Peitu Shengjin decoction. The treatment course was 4 months in both groups. Before and after treatment

pulmonary function was detected

and forced vital capacity (FVC)

forced expiratory volume at the first second (FEV1)

and percentage of FEV1 in estimated value (FEV1%) were recorded. Scores of traditional Chinese medicine (TCM) syndrome

and index of dyspnea (MMRC) were graded. In addition

the levels of interleukin-6 (IL-6)

IL-8

tumor necrosis factor-α (TNF-α)

transforming growth factor-β1 (TGF-β1)

vascular endothelial growth factor (VEGF)

matrix metalloproteinase (MMP-2

MMP-9)

and tissue inhibitor of metalloproteinase-1 (TIMP-1) were detected. Result:The total effective rate was 89.33% in observation group

higher than 73.61% in control group (χ2=6.056

P<0.05). The scores of cardinal symptom

total score of TCM syndrome and score of MMRC in observation group were lower than those in control group (P<0.01). Levels of IL-6

IL-8

TNF-α

TGF-β1

VEGF

MMP-2

MMP-9 and TIMP-1 were all lower than those in control group (P<0.01). Conclusion:Peitu Shengjin decoction can inhibit inflammatory response

regulate growth factor and balance of protease-antiprotease

relieve airway remodeling

alleviate clinical symptoms and improve pulmonary function.

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