Isolation and Identification of Chemical Constituents from  var.

HE Yu-qin; JIN Chen; HUANG Bin; ZHAO Yan-hong; ZHOU Cai-hong; ZHANG Ling

doi:10.13422/j.cnki.syfjx.2018020051

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Isolation and Identification of Chemical Constituents from var.

更新时间：2024-01-04

- Isolation and Identification of Chemical Constituents from var.
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 2, Pages: 51-56(2018)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2018020051
  CLC： R284.1
- Published：2018
- 稿件说明：
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HE Yu-qin, JIN Chen, HUANG Bin, et al. Isolation and Identification of Chemical Constituents from var. [J]. Chinese journal of experimental traditional medical formulae, 2018, 24(2): 51-56.
DOI：

HE Yu-qin, JIN Chen, HUANG Bin, et al. Isolation and Identification of Chemical Constituents from var. [J]. Chinese journal of experimental traditional medical formulae, 2018, 24(2): 51-56. DOI： 10.13422/j.cnki.syfjx.2018020051.

摘要

目的：对丰城鸡血藤正丁醇和石油醚部位的化学成分进行分离，并对所得化合物进行结构鉴定。方法：采用大孔吸附树脂，反复硅胶柱，LH-20型羟丙基葡聚糖凝胶（Sephadex LH-20），RP-HPLC制备柱等技术对丰城鸡血藤正丁醇和石油醚部位进行分离，依据化合物的理化性质并结合现代波谱技术鉴定化合物的结构。结果：最终从丰城鸡血藤正丁醇和石油醚部位分离出15个化合物，包括1个木脂素类化合物，（+）-lyoniresinol-3α-O-D-glucopyranoside（1）；2个三萜类化合物，taraxeron（2），epilupeol（3）；12个黄酮类化合物，鹰嘴豆芽素A-7-O-β-D-吡喃葡萄糖苷（4），芒柄花素-7-O-β-D-呋喃芹糖基-（1→6）-O-β-D-吡喃葡萄糖（5），圆荚草双糖苷（6），8-methylretusin-7-O-β-D-glucopyranoside（7），阿夫罗摩辛-7-O-β-D-吡喃葡糖苷（8），β-galactosyl 1-6β-galactosyl formononetin（9），retusin 8-methyl ether（10），7-hydroxy-4'，6-dimethoxyisoflavone（11），4'-甲氧基-7-羟基异黄酮（12），biochanin A-7-O-β-D-glucoside（13），澳白檀苷（14），6-methoxyisoformononetin（15）。结论：其中8个化合物1，2，3，4，7，9，10，15首次在本植物中分离得到，除化合物2外，其余7个化合物均为首次从本属植物中分离得到。该研究为丰城鸡血藤综合开发及天然植物药理活性研究提供化学依据和物质参考。

Abstract

Objective:The chemical constituents of n-butanol and petroleum ether were separated and the compounds were identified from Millettla nitida var. hirsutissima. Method:The n-butanol and petroleum ether fractions from M. nitida var. hirsutissima were isolated by macroporous adsorption resin chromatography

silica gel column

re-crystallization

Sephadex LH-20 column

reversed phase high-performance liquid chromatography and identified on physicochemical properties and spectral evidences. Result:Finally 15 compounds were isolated from n-butanol and petroleum ether fractions from M. nitida var. hirsutissima

including one neolignan

(+)-lyoniresinol-3α-O-D-glucopyranoside (1); two triterpenoids

taraxeron (2)

epilupeol (3); and twelve flavonoids

biochanin A 7-O-β-D-glucopyranoside (4)

formononetin-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (5)

sphaerobioside (6)

8-methylretusin-7-O-β-D-glucopyranoside (7)

afromosin 7-O-β-D-glucopyranoside (8)

β-galactosyl 1-6β-galactosyl formononetin (9)

retusin 8-methyl ether (10)

7-hydroxy-4'

6-dimethoxyisoflavone (11)

4'-methoxy-7-hydroxyisoflavone(12)

biochanin A-7-O-β-D-glucoside(13)

lanceolarin(14)

and 6-methoxyisoformononetin (15). Conclusion:Compounds 1

10 and 15 were isolated from this the genus Millettia for the first time

and compounds 1

10 and 15 were obtained from this plant for the first time

providing chemical basis and foundation for the comprehensive development and the search for active substances of natural plant.

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