Objective:To explore the clinical efficacy of Qiju Dihuang Tang on patients with xeroma due to Yin deficiency of liver and kidney and its effect on tear secretion. Method:A total of 100 cases (200 eyes) with xeroma due to Yin deficiency of liver and kidney treated at Tongji Medical College

Huangzhong University of Science and Technology

the Central Hospital of Wuhan from January 2015 to January 2017 were selected as research objectives and divided into two groups randomly. All of the cases were provided with the same basic therapy. In addition

sodium hyaluronate eye drops were also provided to control group

while observation group was also given sodium hyaluronate eye drops and Qiju Dihuang Tang. The two groups' clinical efficacy

corneal fluorescein staining (FL)

schirmer I test (SIT)

breakup time of tear film (BUT)

tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6) before and after treatment

as well as the score of national eye institute visual function questionaire-25 (NEI-VFQ-25) were recorded and compared. Result:After 3 courses of treatment

observation group's overall effective rate was 88.0%

which was significant higher than 68.0% of control group(P<0.05). The two groups' FL scores after 3 course treatment were significant lower than those before treatment(P<0.01)

but NEI-VFQ-2 score

SIT

BUT increased (P<0.01). All of the mentioned indexes in observation group was increased more significantly (P<0.01). The two groups' tear TNF-α

IL-6 after 3 courses of treatment were significant lower than those before treatment (P<0.01). And inflammatory indexes in the tear increased more significantly in observation group (P<0.01). Conclusion:Qiju Dihuang Tang helps cases with xeroma due to Yin deficiency of liver and kidney to reduce corneal injury

increase tear secretion

relieve eye inflammation

and improve the quality of life

with a significant clinical efficacy.