Objective:To investigate the efficacy of Sijunzi Tang on bone marrow suppression of lung cancer in chemotherapy with syndrome of deficiency of both Qi and Yin

and tpexplore its effect on serum granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). Method:One hundred and four cases of patients with advanced pulmonary carcinomas were randomly divided into observation group (52 cases) and control group (52 cases). The patients in control group were treated with chemotherapy regimen (TP). Based on the treatment in control group

the patients in observation group additionally received Sijunzi Tang from the first day of chemotherapy

bid

until 1 week after chemotherapy. Degree of bone marrow suppression

symptom score of traditional Chinese medicine (TCM)

leukopenia

and recent clinical efficacy were compared in two between groups. Peripheral blood T-cell subsets CD3+

CD4+ and CD8+ changes were detected in both groups. Application amount of Recombinant Human Granulocyte Colony-stimulating Factor Injection (rhG-CSF) was recorded in both groups

and the levels of GM-CSF and G-CSF in serum were also detected in both groups. Result:One week after treatment

the counts of neutrophils

hemoglobin

platelets

and white blood cells in observation group were obviously higher than those in control group (P<0.01). The incidence of neutropenia and leukopenia was evidently lower than that in the control gorup (P<0.05). One week after treatment

TCM symptom scores and leukopenia scores were remarkably lower than those in control group (P<0.01). Recent efficacy rate was 86.27% in observation group

superior to 66% in control group (P<0.05). Observation group CD3+ and CD4+ in were obviously higher

while CD8+ was lower than those of control group one week after treatment(P<0.01). Application amount of rhG-CSF in observation group was obviously less than that in control group (P<0.01)

and the levels of GM-CSF and G-CSF in serum of observation group were evidently higher than those of control group one week after treatment(P<0.01). Conclusion:Adjuvant therapy of Sijunzi Tang in patients with chemotherapy for late lung cancer with syndrome of deficiency of both Qi and Yin can improve bone marrow suppression degree

reduce occurrence rate of bone marrow suppression

and increase efficacy. Improvement of immunity and up-regulation of GM-CSF and G-CSF levels in serum may be one of its curative pathways.