GAN Jia-he, WANG Chun, SONG Zhi-qian, et al. Effect of Refined Honey Amount on Pharmacokinetics of 9 Different Alkaloids in Fuzi Lizhongwan[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(3): 90-96.
DOI:
GAN Jia-he, WANG Chun, SONG Zhi-qian, et al. Effect of Refined Honey Amount on Pharmacokinetics of 9 Different Alkaloids in Fuzi Lizhongwan[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(3): 90-96. DOI: 10.13422/j.cnki.syfjx.2018030090.
Effect of Refined Honey Amount on Pharmacokinetics of 9 Different Alkaloids in Fuzi Lizhongwan
Objective:To establish a method for the determination of nine alkaloids in plasma at different time points after oral administration of two dosage forms of Fuzi Lizhongwan
in order to determine refined honey whether have any impact on the pharmacokinetic behavior of the main alkaloids. Method:SD rats were given two different kinds of Fuzi Lizhongwan(big honeyed pill of 19.44 g·kg-1 and water-honeyed pill of 19.22 g·kg-1) with different amount of honey.Blood concentrations were measured at different time points after administration
and the concentrations of 9 alkaloids in the plasma were determined by RRLC-TQ-MS.The plasma concentration-time curves were drawn and the pharmacokinetic parameters were calculated. Result:Eight of nine alkaloids were detected in rat plasma.For diester alkaloids
the AUC
Cmax
Tmax and t1/2 of aconitine
mesaconitine and hypaconitine were big honeyed pill>water-honeyed pill
and clearance rate(CL) was the big honeyed pillTmax and t1/2 of benzoylmesaconine and benzoylhypaconine were big honeyed pillCmax and CL were big honeyed pill >water-honeyed pill.Benzoylaconine was not detected.For alcohol amine alkaloids
the AUC
Tmax and t1/2 of aconine
mesaconine and hypaconine were big honeyed pill< water-honeyed pill
and Cmax and CL were big honeyed pill>water-honeyed pill. Conclusion:The refined honey can affect the pharmacokinetic characteristics of the main alkaloid components in Fuzi Lizhongwan.Compared with the water-honeyed pill
times to peak of diester alkaloids in big honeyed pill are extended and the elimination rates are slowed down
which suggesting that refined honey in the formula can play a role in delaying absorption.
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Related Author
WANG Fang
YANG Ming
ZHENG Qin
LI Feng-qin
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ZHANG Pu-zhao
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Related Institution
Formula-pattern Research Center of Jiangxi University of Chinese Medicine
College of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine
Shandong University of Traditional Chinese Medicine
College Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province, Key Laboratory Breeding Base of Co-founded by Sichuan Province and Ministry of Science and Technology
Institute of Basic Theory of Chinese Medicine, China Academy of Chinese Medical Sciences