Objective:To observe the effect of Buyang Huanwutang (BYHWT) on the apoptosis factors in hippocampus and learning and memory abilities of Alzheimer's disease mice. Method:Totally 40 male APP/PS1 double transgenic mice were randomly divided into 5 groups:model group

donepezil group (0.001 g·kg-1)

high-dose

middle-dose and low-dose BYHWT groups (with the dosage of 37.06

18.53

9.26 g·kg-1

representatively). Another 8 C57 mice were used as control group. After 30 days of administration

Morris water maze behavior test was conducted; and after the test

all mice were put to death. Western blot was used to detect the changes in apoptotic factors in hippocampus of the mice:B-cell lymphoma-2 (Bcl-2)

Bcl-2 associated X protein (Bax) and cysteine aspartate protease-3 (Caspase-3). Result:Compared with the control group

the learning and memory abilities of the model group were significantly lower (P<0.01)

Bcl-2 in hippocampus was obviously reduced (P<0.01)

and Bax and Caspase-3 increased significantly (P<0.01). Compared with the model group

high-dose and middle-dose BYHWT groups could significantly improve the learning and memory abilities of the mice

Bcl-2 increased significantly (P<0.01)

and Bax and Caspase-3 decreased significantly (P<0.01). Conclusion:BYHWT can obviously improve the learning and memory abilities of Alzheimer's disease mice

reduce the expressions of Bax and Caspase-3 in hippocampus

and increase the expression of Bcl-2.