Clinical Effect of Wenglitong Capsule Combined with Acupuncture in Treating CP/CPPS with Damp Heat Stasis Syndrome

WANG De-jun; LI Lu-kai; ZHANG Hui

doi:10.13422/j.cnki.syfjx.2018030208

您当前的位置：

首页 >

文章列表页 >

Clinical Effect of Wenglitong Capsule Combined with Acupuncture in Treating CP/CPPS with Damp Heat Stasis Syndrome

更新时间：2024-01-04

- Clinical Effect of Wenglitong Capsule Combined with Acupuncture in Treating CP/CPPS with Damp Heat Stasis Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 3, Pages: 208-213(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2018030208
  CLC： R277.5
- Published：2018
- 稿件说明：
移动端阅览
WANG De-jun, LI Lu-kai, ZHANG Hui. Clinical Effect of Wenglitong Capsule Combined with Acupuncture in Treating CP/CPPS with Damp Heat Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(3): 208-213.
DOI：

WANG De-jun, LI Lu-kai, ZHANG Hui. Clinical Effect of Wenglitong Capsule Combined with Acupuncture in Treating CP/CPPS with Damp Heat Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(3): 208-213. DOI： 10.13422/j.cnki.syfjx.2018030208.

摘要

目的：观察翁沥通胶囊联合针刺的方案治疗慢性前列腺炎/慢性骨盆疼痛综合征（CP/CPPS）湿热瘀滞证临床疗效，及对前列腺液（EPS）炎症因子的影响。方法：将140例患者采用随机按数字表法分为对照组和观察组各70例。对照组采用针刺治疗，观察组在对照组治疗的基础上给予翁沥通胶囊，3粒/次，2次/d，口服。两组疗程均为6周。进行治疗前后美国国立卫生研究院的CP症状指数（NIH-CPSI）评分和中医证候评分；进行治疗前后患者健康问卷-抑郁量表（PHQ）评分和疼痛灾难化量表（PCS）评分；进行治疗前后EPS常规检查；检测治疗前后EPS白细胞介素-1β（IL-1β），肿瘤坏死因子-α（TNF-α），干扰素-γ（IFN-γ），白细胞介素-2（IL-2）水平。结果：观察组临床疗效总有效率为97.01%，高于对照组的86.15%（χ2＝5.095，P<0.05）；观察组中医证候疗效总有效率为97.01%，高于对照组的83.08%（χ2=7.219，P<0.05）；治疗后观察组患者排尿症状、生活质量评分及NIH-CPSI总分均低于对照组（P<0.01）；观察组尿路症状、放射痛症状、性功能障碍、全身症状评分及湿热瘀滞证总分均低于对照组（P<0.01）；治疗后观察组EPS中卵磷脂小体的改善优于对照组（P<0.05）；治疗后观察组PCS评分低于对照组（P<0.01）；治疗后观察组患者EPS中IL-1β，TNF-α，IFN-γ水平均低于对照组，IL-2水平高于对照组（P<0.01）。结论：翁沥通胶囊联合针刺治疗CP/CPPS （湿热瘀滞证）能显著改善患者的症状，减轻焦虑、抑郁，增加EPS中卵磷脂小体，并能抑制炎症反应，减轻炎性损伤，疾病疗效和中医证候疗效均具有明显优势，二者的联合具有协同作用。

Abstract

Objective:To observe the clinical effect of Wenglitong capsule combined with acupuncture in treating chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with damp heat stasis syndrome

and its impact on inflammatory factors of prostatic secretions (EPS). Method:One hundred and forty patients were divided into control group and observation group by random number table. Patients in control group got acupuncture. In addition to the therapy of control group

patients in observation group was also given Wenglitong capsule

3 grains/time

2 times/day. A course of treatment was six weeks. Before and after treatment

scores of CP Symptom Index of National Institutes of Health (NIH-CPSI) and traditional Chinese medicine(TCM) syndromes

patient health questionnaire (PHQ) and pain catastrophizing scale (PCS) were graded. EPS were detected. And levels of interleukin-1β (IL-1β)

interleukin-2 (IL-2)

tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) were also detected. Result:The total effect rate in observation group was 97.01%

which was higher than 86.15% in control group (χ2=5.095

P<0.05). And the total effect rate of TCM symptoms in observation group was 97.01%

which was higher than 83.08% in control group (χ2=7.219

P<0.05). After treatment

scores of urination symptoms

quality of life

NIH-CPSI and PCS in observation group were all lower than those in control group (P<0.01). Scores of urinary tract symptoms

radiating pain symptoms

sexual dysfunction

evaluation of systemic symptoms and damp heat stasis syndrome were all lower than those in control group (P<0.01). Lecithin body of EPS in observation group was superior to that in control group (P<0.05). And levels of IL-1β

TNF-α

IFN-γ were all lower than those in control group

and the level of IL-2 was higher than that in control group (P<0.01). Conclusion:Wenglitong capsule combined with acupuncture can ameliorate symptoms of patients with CP/CPPS

relieve anxiety and depression

increase lecithin body of EPS

inhibit inflammation

and reduce inflammatory damage

with a better efficacy and TCM symptoms. Due to their good synergy.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Acupuncture Combined with Modified Shengyutang on Clinical Efficacy and T-lymphocyte Subsets in Patients with Cervical Spondylotic Radiculopathy of Qi-blood Deficiency

Comprehensive Evaluation of Acupuncture for Secondary Dysmenorrhea Based on Health Technology Assessment

Protective Effect against Helicobacter pylor Gastritis in Mice by Flavonoid Combinations of Alpiniae Officinarum Rhizoma via Inhibition of PI3K/Akt Pathway

Protective Effect of Taohong Siwutang on Cerebral Ischemia-reperfusion Injury Based on A1/A2 Phenotype Transformation of Astrocytes Mediated by JAK2/STAT3 Pathway

Influence of Guizhi Jia Longgu Mulitang on Expression of IL-10 and TNF-α in Insomnia Rats with Sensory Dysfunction Dominated by Lung

Related Author

WANG Qin-jian

WANG Yan

WU Xue

LI Zhiran

HU Jing

LIAO Xing

SUN Weiwei

LUO Xin

Related Institution

Henan Province Hospital of Traditional Chinese Medicine

Beijing Hospital of Traditional Chinese Medicine，Capital Medical University，Beijing Institute of Traditional Chinese Medicine， Beijing Evidence-based Chinese Medicine Center

Center for Evidence-based Chinese Medicine， Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

Hubei Engineering Research Center for Traditional Chinese Medicine Processing

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰