GE Xun, CAO Guang-shang, SUN Hong-sheng, et al. Effect of Active Components of Epimedii Folium in Promoting Proliferation and Differentiation of Osteoblasts[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(3): 228-234.
DOI:
GE Xun, CAO Guang-shang, SUN Hong-sheng, et al. Effect of Active Components of Epimedii Folium in Promoting Proliferation and Differentiation of Osteoblasts[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(3): 228-234. DOI: 10.13422/j.cnki.syfjx.2018030228.
Effect of Active Components of Epimedii Folium in Promoting Proliferation and Differentiation of Osteoblasts
The incidence of various kinds of bone diseases represented by osteonecrosis of femoral head (ONFN) has been increasing in recent years. Epimedii Folium has been widely used in clinical department of orthopedics of traditional Chinese medicine (TCM) as a commonly used drug for reinforcing kidney and growing bone
with a significant effect in the treatment of various bone diseases. However
it is an urgent problem in clinical medication and relevant drug R&D to define the functions of components of Epimedii Folium. In recent years
it has been found that icariin
icariside
total flavonoids of herba Epimedii Folium
Epimedii Folium polysaccharides and some microelements in Epimedii Folium have the effect in promoting osteoblast proliferation and differentiation. In particular
studies on the pharmacological mechanisms of icariin
icariside and total flavonoids of herba Epimedii Folium in the molecular filed have made a great progress. A large number of experimental studies have shown that the components mentioned above could promote the formation of bone morphogenetic protein (BMP2) and the protein synthesis of osteoprotegerin (OPG) by controlling the expressions of osteoblast-related genes and regulating the signal pathway
and explained the intrinsic mechanism that Epimedii Folium could promote osteoblast proliferation and differentiation at the molecular level. Regarding the effect of Epimedii Folium polysaccharides and microelements in Epimedii Folium in promoting osteoblast proliferation and differentiation
the researchers only carried out the confirmatory experiment
without further exploring the in-depth mechanism. This article summarizes the study advance of the effect of various components in promoting proliferation and differentiation of osteoblasts based on main effective components icariin
icariside
total flavonoids of herba Epimedii Folium
Epimedii Folium polysaccharides and some microelements in Epimedii Folium
in order to provide a theoretical reference for new drugs research and development and improving the clinical efficacy.