Objective: To optimize the main extraction process of Xiaochuan prescription based on allergic asthma model of rats. Method: The total number of cells in bronchoalveolar lavage fluid(BALF)

levels of interleukin-4(IL-4)

IL-5

interferon-γ(IFN-γ)

immunoglobulin E(IgE) in serum

morphological changes of lung tissue and other pharmacodynamics indexes on model rats combined with transfer rates of index components in medicinal materials were used as evaluating indicators for four extraction processes of Xiaochuan prescription. Result: The four main processes all can increase the total number of cells in BALF and reduce the role of lung inflammation and emphysema in the model rats;compared with the model group

the levels of IL-4

IFN-γ and IgE in the fourth process were significantly different(P<0.01)

and the level of IL-5 was signigicantly different(P<0.05);the total transfer rate of ephedrine hydrochloride and pseudoephedrine hydrochloride was 58.97%

the total transfer rate of prim-O-glucosylcimifugin and 5-O-methylvisammioside was 63.88%

the transfer rate of schisandrin was 60.26% and transfer rate of loganin was 62.79% in the fourth process;the fourth process had the highest transfer rates of all index components. Conclusion: The fourth process group is the best by evaluating in the efficacy screening test and transfer rates of index components

and it can be used as the main extraction process of Xiaochuan prescription.