Clinical Efficacy of Qinhuang Mixture in Treating Non-Hodgkin Lymphoma with Syndrome of Intermingled Deficiency and Excess

Zhang Hong; LYU Ling-ling; ZHU Wei-rong; ZHAO Xia; Wang Li; ZHAO Wei-li; RUAN Ming; ZHANG Wei-yu; CHEN Jing-xian; ZHENG Lan; SHEN Xiao-heng

doi:10.13422/j.cnki.syfjx.2018040167

您当前的位置：

首页 >

文章列表页 >

Clinical Efficacy of Qinhuang Mixture in Treating Non-Hodgkin Lymphoma with Syndrome of Intermingled Deficiency and Excess

更新时间：2024-01-04

- Clinical Efficacy of Qinhuang Mixture in Treating Non-Hodgkin Lymphoma with Syndrome of Intermingled Deficiency and Excess
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 4, Pages: 167-173(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2018040167
  CLC： R273
- Published：2018
- 稿件说明：
移动端阅览
Zhang Hong, LYU Ling-ling, ZHU Wei-rong, et al. Clinical Efficacy of Qinhuang Mixture in Treating Non-Hodgkin Lymphoma with Syndrome of Intermingled Deficiency and Excess[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(4): 167-173.
DOI：

Zhang Hong, LYU Ling-ling, ZHU Wei-rong, et al. Clinical Efficacy of Qinhuang Mixture in Treating Non-Hodgkin Lymphoma with Syndrome of Intermingled Deficiency and Excess[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(4): 167-173. DOI： 10.13422/j.cnki.syfjx.2018040167.

摘要

目的：探讨中药小复方芩黄合剂对虚实夹杂型非霍奇金淋巴瘤患者生活质量及免疫功能的影响。方法：根据真实世界研究方法，由患者自愿选择入组，收集上海交通大学医学院附属瑞金医院2015年1月—2016年12月治疗或随访的非霍奇金淋巴瘤患者，分为观察组和对照组，观察组患者在常规化疗或随访期间服用芩黄合剂。对照组患者在常规化疗和随访期间不服用芩黄合剂。观察期为6个月，全部患者到达研究终点后比较两组患者卡氏评分（Kanofsky score，KPS）、生活质量评分（EORTC-QLQ-C30）、外周血细胞免疫、体液免疫及免疫相关细胞因子水平。结果：共收集有效病例222例，观察组74例，其中20例处于化疗期，54例处于随访期；对照组148例，其中87例处于化疗期，61例处于随访期。治疗后观察组KPS评分好转率明显优于对照组（P<0.05），生活质量（EORTC-QLQ-C30）评分中观察组治疗后疲乏、便秘、腹泻症状评分低于对照组（P<0.05），躯体、情绪功能及总体健康状况评分高于对照组（P<0.05）。治疗后观察组外周血T淋巴细胞亚群CD3+，CD4+水平，CD4+/CD8+，免疫球蛋白G（Immunoglobulin G，IgG），免疫球蛋白M（IgM），白细胞介素（interleukin，IL）-2，补体C3水平高于对照组（P<0.05），IL-6，IL-8，IL-10水平低于对照组（P<0.05）。结论：芩黄合剂能有效地改善虚实夹杂型非霍奇金淋巴瘤患者的生活质量及免疫功能。

Abstract

Objective: To study the effect of Qinhuang mixture on the life quality and immune function of patients with non-Hodgkin lymphoma with syndrome of intermingled deficiency and excess. Method: By the Real World Study method

patients were divided into observation group and control group according to their own willing. All patients received routine chemotherapy and followed up at Ruijin Hospital during January 2015 and December 2016.Patients in observation group took Qinhuang mixture during routine chemotherapy and follow-up period

while patients in control group did not take Qinhuang mixture. The observation period was 6 months. Kanofsky score (KPS)

quality of life score (EORTC-QLQ-C30)

peripheral blood cell immunity

humoral immunity and immune-related cytokine levels were compared between two groups after all patients reached the end of the study. Result: A total of 222 valid cases were collected. Specifically

74 cases were in the observation group

including 20 cases in chemotherapy and 54 cases in the follow-up period; and 148 cases were in control group

including 87 cases in the chemotherapy period and 61 cases in the follow-up period. The improvement rate of KPS score in observation group was significantly superior to that in control group (P<0.05). Scores of fatigue

constipation and diarrhea in EORTC-QLQ-C30 in observation group were lower than those in control group (P<0.05). Physical

emotional function and overall health status scores of observation group were higher than those of the control group (P<0.05). Levels of CD3+

CD4+

CD4+/CD8+ ratio

immunoglobulin G (IgG)

immunoglobulin M (IgM)

interleukin (IL)-2 and alexin C3 in peripheral blood of the observation group were higher than those in control group (P<0.05)

whereas IL-6

IL-8 and IL-10 were lower than those in control group (P<0.05). Conclusion: Qinhuang mixture can effectively improve the quality of life and immune function of patients with non-Hodgkin lymphoma with syndrome of intermingled deficiency and excess.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of Jianpi Bushen Prescription on Hematopoiesis and Immune System in Tumor Patients After Radiotherapy

Effect of Modified Gualou Zhishitang Combined with Piperacillin Sodium and Tazobactam Sodium on Immune Function and Serum Levels of Inflammatory Cytokines in Patients with Stroke-associated Pneumonia with Syndrome of Phlegm-heat Accumulation in Lung

Clinical Efficacy of Qimai Qinlou Prescription in Treating Elderly Community-acquired Pneumonia （Non-severe） with Qi and Yin Deficiency and Phlegm-heat Obstructing Lung Syndrome

Anti-Allergic Rhinitis Mechanism of Bikangfu via Regulation of IL-35/STAT3， Inhibition of Eosinophil Activation and Improvement of Immune Function

Observe Impact Modified Guipitang Administration Combined with Hot Pressing of Traditional Chinese Medicine on Rehabilitation in Patients with Deficiency of Qi and Blood Syndrome Breast Cancer Postoperative

Related Author

SUN Junyang

HE Dongchu

WANG Yongfei

ZHU Qinxian

CAO Xu

GU Bolin

ZHU Jianjun

LIU Yishu

Related Institution

Central Theater General Hospital of PLA

Hubei University of Chinese Medicine

The Second Affiliated Hospital of Soochow University

The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine（TCM）

The Second Affiliated Hospital of Hainan Medical College

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰