Objective:To investigate the efficacy of Jiawei Tongguan Tang combined with massage manipulation in treating uroschesis after ischemic stroke and observe its effect on serum levels of substance P (SP)

calcitonin-gene related peptide (CGRP) and the antioxygenation. Method:One hundred and four patients with ischemic stroke were selected as object

study and randomly divided into observation group(52 cases)and control group(52 cases)by referring to random number table method. All cases were given with conventional measures according to ‘Chinese Stroke Rehabilitation Treatment Guidelines’. The patients in control group also received bladder function training and routine urinary retention therapy. On basis of the treatment in control group

the patients in observation group were also treated with modified Tongguan Tang combined with massage manipulation. Both groups were treated for 4 weeks. A single urine output

urinary catheter indwelling time

main traditional Chinese medicine symptom scores

and clinical efficacy were compared between two group. Serum levels of SP

CGRP

xanthine oxidoreductase (XOR)

malondialdehyde (MDA) and superoxide dismutase (SOD) were detected in both groups. Result:After treatment

the single urine output

maximum urine flow

the detrusor pressure at the maximum urine rate

and maximum urinary bladder capacity in observation group were obviously higher than those in control group

while the catheter indwelling time was significantly shorter than that in the control group (P<0.01). Scores of acraturesis

abdominal distension

fatigue and weakness in observation group were lower than those in the control group after treatment (P<0.01). The total effective rate was 90.2% in the observation group

higher than 72% in control group (P<0.05). After treatment

serum levels of SP and CGRP in observation group were remarkably higher than those in control group (P<0.01). As compared to control group

the decrease in serum levels of XOD and MDA and the increase in SOD in observation group were more obvious

in observation group after treatment (P<0.01). Conclusion:Jiawei Tongguan Tang combined with massage manipulation has a definite curative effect in treating uroschesis after ischemic stroke

which may be related to up-regulating levels of SP and CGRP and enhancing the antioxygenation.