Objective:To observe the clinical efficacy of Yupingfeng granules in preventing and treating the recurrent common cold and recuperating the Qi-deficient constitution. Method:A total of 229 subjects with Qi-deficient constitution were recruited in this trial and randomly divide into treatment group (174 cases) and control group (55 cases). The subjects in treatment group orally took Yupingfeng granules

while the subjects in control group took Yupingfeng granules placebo. Each group was treated for 3 months

and the follow-up period was 1 year. Clinical efficacy was observed before treatment

3

6

9

12 months after treatment. Result:The study was finished well with a comparable baseline. The number of the recurrent common cold in treatment group was lower than that in control group after treatment (P<0.05); the total score of clinical features of the Qi-deficient constitution in treatment group was lower than that in control group (P<0.05)

and the reductive ratio of total score in treatment group was 49.82%

and each of the reductive ratio of clinical features in treatment group was higher than that in control group. After 3 treatment courses

the appearance of the first time of colds in treatment group was significantly expanded as compared with control group (P<0.05)

and the scores of clinical features of the Qi-deficient constitution in treatment group were significant lower than those in control group at different time points (P<0.01) Conclusion:Yupingfeng granules can effectively reduce the numbers of the recurrent common cold of the Qi-deficient constitution

with some preventive effect on recurrence of colds and recuperate the Qi-deficient constitution.