Efficacy of Traditional Chinese Medicine in Treatment of Unstable Angina

GAO Wu-lin; DAI Guo-hua; SHI Xiao-jing; ZHAO Fang; YUAN Chen-hao; BI Dong-xue

doi:10.13422/j.cnki.syfjx.20180623

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Efficacy of Traditional Chinese Medicine in Treatment of Unstable Angina

更新时间：2024-01-04

- Efficacy of Traditional Chinese Medicine in Treatment of Unstable Angina
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 7, Pages: 228-234(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20180623
  CLC： R259
- Published：2018
- 稿件说明：
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GAO Wu-lin, DAI Guo-hua, SHI Xiao-jing, et al. Efficacy of Traditional Chinese Medicine in Treatment of Unstable Angina[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(7): 228-234.
DOI：

GAO Wu-lin, DAI Guo-hua, SHI Xiao-jing, et al. Efficacy of Traditional Chinese Medicine in Treatment of Unstable Angina[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(7): 228-234. DOI： 10.13422/j.cnki.syfjx.20180623.

摘要

目的：探讨中医药干预冠心病不稳定性心绞痛患者的临床疗效及其影响因素。方法：采用队列研究设计，住院期间以应用中药注射剂≥ 7 d为暴露组。随访期间以应用中成药或中药汤剂≥ 28 d为暴露组。采用病历调查收集患者住院期间的一般资料、中药使用情况及终点事件发生情况。电话随访患者出院至2015年12月31日中药使用情况以及终点事件发生情况。单因素分析采用卡方检验。多因素分析采用多元Logistic回归分析法。结果：住院期间终点事件发生前3位为血运重建（30.93%），心肌梗死（25.77%），脑卒中（18.56%）。中医药治疗（OR=2.651），年龄（OR=1.881），抗栓治疗（OR=1.088），抗心肌缺血治疗（OR=1.150），降脂治疗（OR=1.241）是心肌梗死的相关因素。中医药治疗（OR=2.972）是脑卒中的相关因素。随访期间终点事件发生前3位为心血管再入院（11.66%），血运重建（7.13%），脑卒中（3.89%）。中医药治疗（OR=1.515），年龄（OR=1.892）是心源性死亡的相关因素。结论：中医药治疗、年龄和性别等是冠心病不稳定性心绞痛患者终点事件发生的相关因素，其中中医药治疗能够减少冠心病不稳定性心绞痛患者住院期间心肌梗死、脑卒中和随访期间心源性死亡的发生。

Abstract

Objective: To investigate the clinical efficacy of traditional Chinese medicine(TCM) in the treatment of unstable angina. Method: A cohort study was performed in this study. During the period of hospitalization

the exposure group was established through the application of TCM injection for at least 7 days. During the follow-up period

the exposure group was established through the application of Chinese medicine or TCM decoction for at least 28 days. The general information

application of TCM and endpoint events of patients were collected based on the medical records during hospitalization. The application of TCM and endpoint events of patients from the date of discharge to December 31

2015 were followed up by telephone. The single factor analysis was made by chi-square test. The multivariate analysis was performed by multiple logistic regression analysis. Result: During hospitalization

top three endpoint events were revascularization (30.93%)

myocardial infarction (25.77%) and stroke (18.56%). TCM therapy (OR=2.651

CI=1.089-6.454)

age (OR=1.881

CI=0.817-2.950)

antithrombotic therapy (OR=1.088

CI=1.026-1.296)

anti-myocardial ischemia therapy (OR=1.150

CI=0.051-2.445)

and lipid-lowering therapy (OR=1.241

CI=1.085-1.683) were the factors related to myocardial infarction. TCM(OR=2.972

CI=1.113-7.930) was associated with stroke. During the follow-up period

the endpoint events were cardiovascular readmission (11.66%)

revascularization (7.13%) and stroke (3.89%). TCM(OR=1.515

CI=0.299-1.886) and age (OR=1.892

CI=0.813-1.979) were related factors of cardiac death. Conclusion: TCM

age and gender are the related factors of endpoint events in patients with unstable angina. TCM can reduce the incidences of myocardial infarction and stroke in patients with unstable angina during hospitalization

and cardiac death during the follow-up period.

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