Objective: To investigate the efficacy of new Guanxin Suhe Huoxue decoction in treating chronic stable angina pectoris (SAP) with syndrome of cold and cold stagnation and observe its effect on serum levels of reactive oxygen species (ROS)

periostin and cardiotrophin-1 (CT-1).Method: One hundred and eighteen patients with chronic SAP were selected and randomly divided into control group 59 cases and observation group 59 cases. Both groups received routine western medicine according to Guideline for Diagnosis and Treatment of Chronic Stable Angina. Observation group was also given with new Guanxinsuhe Huoxue decoction

1 dose/time

bid. Both groups were treated for 12 weeks. Symptom scores of syndrome of cold and cold stagnation

attack frequency and degree of angina pectoris

quality of life scores in Seattle Angina Questionnaiire (SAQ)

and efficacy were compared between two groups. Blood lipid levels were detected in both groups by fully automatic biochemical analyser before and after treatment; and the serum levels of ROS

periostin and CT-1 were also measured in two groups.Result: As compared to control group

the symptom scores of syndrome of cold and cold stagnation

frequency of angina pectoris

and attack duration of angina pectoris were significantly reduced

while scores of SAQ life quality indexes were obviously increased in patients with new Guanxinsuhe Huoxue decoction (P<0.01). The total efficacy was 93.1% in observation group better than 77.19% in control group (P<0.05). After treatment

as compared to control group

the levels of triglycerides (TG)

total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in observation group were obviously decreased

while high-density lipoprotein cholesterol (HDL-C) was higher (P<0.01). Serum levels of ROS

periostin

and CT-1 in the observation group were evidently lower than those in control group (P<0.01).Conclusion: New Guanxin Suhe Huoxue decoction can improve clinical symptoms of traditional Chinese medicine and life quality

alleviate the degree of angina pectoris attacks

and increase efficacy in treating chronic stable angina pectoris with cold and cold stagnation syndrome. One of its mechanisms may be associated with inhibiting levels of ROS

periostin and CT-1.