Colorectal cancer has the highest incidence among malignant digestive tract tumors

with a low survival rate in five years. In recent years

with the changes in diet structure

its incidence has increased in China year by year

and become a serious threat to human health. Therefore

it is of great significance to study its occurrence and development mechanisms and effective prevention and treatment methods. Exosomes are a type of secretory vesicles with a diameter of about 30-100 nm secreted by cells

and carry specific molecules on surface. They can be internalized through receptor-ligand binding or endocytosis

or fused with the target cell membrane

then release substances into target cells

and induce target cells to change their physiological state

so as to play an important role in intercellular exchanges. In tumor tissues

exosomes

as an important component in tumor microenvironment

can promote colorectal cancer epithelial-mesenchymal transition

guide specific metastasis of tumor cells among organs

induce drug resistance of colorectal cancer cells

and participate in the anti-tumor immunity effect by promoting tumor angiogenesis. Therefore

further study of exosomes in colorectal cancer is conducive to finding the effective methods to prevent and treat colorectal cancer. Meanwhile

because exosomes usually contain a variety of specific molecules

they are expected to be ideal tumor markers in the diagnosis and prognosis of colorectal cancer. Traditional Chinese medicine(TCM) therapy takes ‘overall concept’ and ‘treatment based on syndrome differentiation’ as the basic principle

take effect through multiple links

multiple channels and multiple targets

plays an important role in reducing the recurrence and metastasis rate of colorectal cancer and improving the prognosis of patients with colorectal cancer

and has become an important component of the comprehensive therapy of colorectal cancer. Exosomes widely affects the occurrence and development of colorectal cancer

which is consistent with TCM therapy for colorectal cancer in multiple links

multiple pathways and multi-targets. From this perspective

a more comprehensive study may be made on the mechanisms of TCM for the prevention and treatment of colorectal cancer.