Objective: To investigate the changes in vascular endothelial growth factor (VEGF)

endostatin (ES)

angiogenesis factors (ANG)

angiostatin (AS)

matrix metalloproteinase-9 (MMP-9) and tissue metalloproteinase inhibitor (TIMP) in tissues of nude mice with rectal cancer metastasis model

and the intervention mechanism of Jianpi Xiaoai prescription.Method: HCT116 cells were injected into the BALB/C-nu nude mice

so as to establish the model of colorectal cancer metastasis. The model nude mice were divided into model group and Jianpi Xiaoai prescription group; and control group was also set up. After 4 weeks of administration

the expression of vascular factor in colon

liver

lung and tumor tissues of nude mice was measured by Western blot.Result: VEGF

MMP-9 and TIMP-1 of colon

liver

lung and tumor tissues in HCT116 rectal cancer model nude mice increased significantly (P<0.05

P<0.01); ANG in colon

liver and tumor tissues was significantly increased (P<0.05

P<0.01); ES was significantly lower in colon

lung and tumor tissues

while as significantly reduced in liver

lung and tumor tissues (P<0.05). Colon MMP-9

tumor TIMP

liver tissue ANG

MMP-9 and lung tissue VEGF were significantly decreased in Jianpi Xiaoai prescription group

whereas AS was significantly increased (P<0.05) in lung tissues.Conclusion: The expressions of VEGF

ANG and MMP-9 of colon

liver

lung and tumor tissues in HCT116 colorectal cancer model nude mice increase

while ES

AS reduce

and TIMP rose. Jianpi Xiaoai prescription can comprehensively improve the anti-tumor angiogenesis capacity.