Clinical Efficacy of Jianpi Yangxue Qufeng Decoction in Treating Patients with Blood Deficiency and Wind Dryness Type Atopic Dermatitis and Its Effect on Skin Barrier Function

WANG Li-fen; YE Jian-zhou; YANG Xue-song

doi:10.13422/j.cnki.syfjx.20180722

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Clinical Efficacy of Jianpi Yangxue Qufeng Decoction in Treating Patients with Blood Deficiency and Wind Dryness Type Atopic Dermatitis and Its Effect on Skin Barrier Function

更新时间：2024-01-04

- Clinical Efficacy of Jianpi Yangxue Qufeng Decoction in Treating Patients with Blood Deficiency and Wind Dryness Type Atopic Dermatitis and Its Effect on Skin Barrier Function
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 13, Pages: 178-182(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20180722
  CLC： R275.9
- Published：2018
- 稿件说明：
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WANG Li-fen, YE Jian-zhou, YANG Xue-song. Clinical Efficacy of Jianpi Yangxue Qufeng Decoction in Treating Patients with Blood Deficiency and Wind Dryness Type Atopic Dermatitis and Its Effect on Skin Barrier Function[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(13): 178-182.
DOI：

WANG Li-fen, YE Jian-zhou, YANG Xue-song. Clinical Efficacy of Jianpi Yangxue Qufeng Decoction in Treating Patients with Blood Deficiency and Wind Dryness Type Atopic Dermatitis and Its Effect on Skin Barrier Function[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(13): 178-182. DOI： 10.13422/j.cnki.syfjx.20180722.

摘要

目的：探讨健脾养血祛风汤治疗血虚风燥型特应性皮炎（atopic dermatitis，AD）患者临床疗效及对皮肤屏障功能的影响。方法：以云南省中医医院在2016年3月至2017年5月收治的132例AD患者为研究对象，遵循成组序贯设计法分为治疗组与对照组（各66例）。两组患者同时给予外用白凡士林，在此基础上，对照组患者口服氯雷他定片，治疗组给予健脾养血祛风汤，两组均进行4周治疗，结束后对两组患者疗效，Th1/Th2细胞因子与免疫球蛋白E（immunoglobulin E，IgE），皮肤屏障功能，特应性皮炎积分（scoring atopic dermatitis index，SCORAD）与瘙痒视觉模拟评分（visual analogue scale，VAS）进行比较。结果：治疗组患者总有效率为95.45%，对照组为84.85%，治疗组高于对照组（P<0.05）；与本组治疗前比较，治疗后两组AD患者血清中白细胞介素-4（interleukin-4，IL-4）与IgE水平明显降低，白细胞介素-2（interleukin-2，IL-2）明显升高，且治疗组明显优于对照组（P<0.05）；与本组治疗前比较，治疗后两组AD患者经皮水分丢失（transepidermal waterloss，TEWL）水平明显降低，皮脂含量与角质层含水量明显升高，且治疗组明显优于对照组（P<0.05）；通过治疗，两组AD患者特应性皮炎SCORAD评分与瘙痒VAS均明显降低，且治疗组明显低于对照组（P<0.05）。结论：健脾养血祛风汤对血虚风燥型AD具有积极的治疗效果，可以明显调节血虚风燥型AD患者Th1/Th2细胞因子平衡，改善皮肤屏障功能，降低皮损与瘙痒程度。

Abstract

Objective: To study the clinical efficacy of Jianpi Yangxue Qufeng decoction in treating patients with blood deficiency and wind dryness type atopic dermatitis (AD) and its effect on skin barrier function. Method: Totally 132 cases of patients with blood deficiency and wind dryness type ad treated in our hospital from March 2016 to May 2017 were selected and divided into two groups according to group sequential design

with 66 cases in clinical group and 66 in control group. In addition to the external use of albolene

the control group was given Loratadine Tablets

while the clinical group was given Jianpi Yangxue Qufeng decoction. The course of treatment was 4 weeks. The treatment effect

Th1/Th2 cytokines and immunoglobulin E (IgE)

skin barrier function

scoring atopic dermatitis index (SCORAD) and pruritus visual analogue scale (VAS) were compared. Result: Compared with 84.85% in control group

the total effective rate of clinical group was 95.45%. There was a significant increase (P<0.05). Compared with before treatment

interleukin (IL)-4 and IgE of the two groups after treatment decreased

while IL-2 increased (P<0.05). Compared with control group

the levels of IL-4 and IgE in patients of experimental group were lower after treatment

while IL-2 was higher (P<0.05). Compared with before treatment

transepidermal waterloss (TEWL) of the two groups after treatment decreased

while the sebum content and corneous layer water content increased (P<0.05). Compared with control group

the level of TEWL in patients of the experimental group was lower after treatment

while the sebum content and corneous layer water content were higher (P<0.05). Compared with before treatment

SCORAD scores and pruritus VAS scores in the two groups after treatment decreased (P<0.05). Compared with control group

SCORAD and pruritus VAS scores in patients of experimental group were lower after treatment (P<0.05). Conclusion: Jianpi Yangxue Qufeng decoction has a better effect on blood deficiency and wind dryness type AD

and can significantly improve Th1/Th2 cytokines and skin barrier function and reduce skin lesion and itching.

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