Clinical Efficacy of Bushen Huatan Yizhi Decoction Combined with Butylphthalide and Effect on Oxidative Stress, Hemorheology and Cognitive Function in Patients with Alzheimer's Disease

WANG Shu; ZHANG Xue; MA Ying-rui; ZHAO Ji-bo

doi:10.13422/j.cnki.syfjx.20180797

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Clinical Efficacy of Bushen Huatan Yizhi Decoction Combined with Butylphthalide and Effect on Oxidative Stress, Hemorheology and Cognitive Function in Patients with Alzheimer's Disease

更新时间：2024-01-04

- Clinical Efficacy of Bushen Huatan Yizhi Decoction Combined with Butylphthalide and Effect on Oxidative Stress, Hemorheology and Cognitive Function in Patients with Alzheimer's Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 7, Pages: 212-216(2018)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.20180797
  CLC： R749.16
- Published：2018
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WANG Shu, ZHANG Xue, MA Ying-rui, et al. Clinical Efficacy of Bushen Huatan Yizhi Decoction Combined with Butylphthalide and Effect on Oxidative Stress, Hemorheology and Cognitive Function in Patients with Alzheimer's Disease[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(7): 212-216.
DOI：

WANG Shu, ZHANG Xue, MA Ying-rui, et al. Clinical Efficacy of Bushen Huatan Yizhi Decoction Combined with Butylphthalide and Effect on Oxidative Stress, Hemorheology and Cognitive Function in Patients with Alzheimer's Disease[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(7): 212-216. DOI： 10.13422/j.cnki.syfjx.20180797.

摘要

目的：探讨补肾化痰益智方联合丁苯酞对阿尔茨海默病（Alzheimer's disease，AD）患者氧化应激、血流变学及认知功能的影响。方法：2014年3月-2016年4月齐齐哈尔医学院附属第三医院共收治127例AD患者，以该批患者为研究对象，按随机数字表法分为治疗组（63例），对照组（64例）。两组患者同时给予丁苯酞软胶囊，在此基础上，治疗组加服补肾化痰益智方，连续治疗3个月后，对两组患者临床疗效，氧化应激、血液流变学与简易智力状态检查法（mini-mental state examination，MMSE）量表评分进行比较。结果：治疗组患者总有效率为93.65%，对照组为81.25%，治疗组高于对照组（P<0.05）；经治疗，两组AD患者全血高、低切黏度，红细胞聚集指数与红细胞压积均明显降低，且治疗组明显低于对照组（P<0.05）；与治疗前比较，治疗后，两组患者超氧化物歧化酶（super oxide dismutase，SOD），谷胱甘肽过氧化物酶（glutathione peroxidase，GPX-3）及过氧化氢酶（catalase，CAT）均明显提高，丙二醛（malonyldialdehyde，MDA）明显降低，且治疗组效果明显优于对照组（P<0.05）；与治疗前比较，治疗后两组MMSE评分及记忆力、注意力和计算力、定向力、语言能力、回忆能力均明显改善，且治疗组明显优于对照组（P<0.05）。结论：补肾化痰益智方联合丁苯酞可以明显提高AD患者的认知功能，改善患者血液流变学，降低氧化刺激损伤，因此对AD具有积极的治疗效果。

Abstract

Objective: To study the clinical efficacy of Bushe Huatan Yizhi decoction combined with butylphthalide and effect on oxidative stress

hemorheology and cognitive function in patients with Alzheimer's disease (AD). Method: The 127 patients with AD treated in The Third Affiliated Hospital

Qiqihar Medical College from March 2014 to April 2016 were selected in this study and divided into two groups according to the random number table

with 63 cases in treatment group and 64 cases in control group. Patients in control group were treated with butylphthalide soft capsules

and on this basis

the patient in treatment group were given with additional Bushe Huatan Yizhi decoction. After 3 months treatment

the treatment efficacy

oxidative stress

hemorheology and mini-mental state examination (MMSE) scores were compared. Result: The total effective rate was 93.65% in treatment group

higher than 81.25% in control group (P<0.05). After treatment

the hematocrit

the whole blood viscosity at low shear rate

whole blood viscosity

erythrocyte aggregation index were decreased significantly in both groups

and the levels in treatment group were lower than those in control group (P<0.05). As compared with the conditions before treatment

the levels of malonyldialdehyde (MDA) were decreased while super oxide dismutase (SOD)

glutathione peroxidase (GSH-Px) and catalase (CAT) were increased in both groups after treatment

and the effect was more obvious in treatment group (P<0.05). After treatment

MMSE scores and the scores of memory

attention

computational power

orientation

language ability

and recall ability were improved in both groups

and the effects were more obvious in treatment group (P<0.05). Conclusion: Bushe Huatan Yizhi decoction combined with butylphthalide can significantly improve cognitive function and hemorheology

and lower oxidative stress levels in patients with AD

so it has positive therapeutic effect on AD.

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