Clinical Efficacy of Fufang Wutou Microemulsion on Rheumatoid Arthritis at Active Stage with Cold Dampness Syndrome

LI Yu-kui; FENG Chuan-bo; LIU Ai-zhen; JIA Jiang

doi:10.13422/j.cnki.syfjx.20180827

您当前的位置：

首页 >

文章列表页 >

Clinical Efficacy of Fufang Wutou Microemulsion on Rheumatoid Arthritis at Active Stage with Cold Dampness Syndrome

更新时间：2024-01-04

- Clinical Efficacy of Fufang Wutou Microemulsion on Rheumatoid Arthritis at Active Stage with Cold Dampness Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 8, Pages: 194-199(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20180827
  CLC： R259
- Published：2018
- 稿件说明：
移动端阅览
LI Yu-kui, FENG Chuan-bo, LIU Ai-zhen, et al. Clinical Efficacy of Fufang Wutou Microemulsion on Rheumatoid Arthritis at Active Stage with Cold Dampness Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(8): 194-199.
DOI：

LI Yu-kui, FENG Chuan-bo, LIU Ai-zhen, et al. Clinical Efficacy of Fufang Wutou Microemulsion on Rheumatoid Arthritis at Active Stage with Cold Dampness Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(8): 194-199. DOI： 10.13422/j.cnki.syfjx.20180827.

摘要

目的：探讨复方乌头微乳剂治疗活动期类风湿性关节炎（RA）寒湿痹阻证的临床疗效及对血清C-反应蛋白（CRP），肿瘤坏死因子-α（TNF-α），白细胞介素-1（IL-1）和IL-6等炎症因子的影响。方法：将120例符合要求的患者采用区组随机法，分为对照组和观察组各60例。两组患者均口服美洛昔康片，7.5 mg/次，1次/d；和白芍总苷胶囊，2粒/次，3次/d。对照组采用双氯芬酸二乙胺乳胶剂，按照痛处面积大小，适量外用，3次/d。观察组采用复方乌头微乳剂，根据痛处面积大小，适量外用，3次/d。两组疗程均为连续治疗4周。记录治疗前后关节疼痛和关节压痛评分，肿胀、关节僵硬、关节活动不利等主要临床症状评分；评价治疗前后疾病活动程度（DAS28）评分，简化的疾病活动性指数（SDAI），健康评价问卷评分（HAQ）；检测血沉（ESR），CRP，类风湿因子（RF），TNF-α，IL-1和IL-6水平；进行皮肤刺激和毒副反应观察。结果：观察组ACR20，ACR50分别为91.67%，56.67%，分别高于对照组的68.33%，36.67%（P<0.05，P<0.01），两组患者ACR70组间比较，差异无统计学意义；观察组关节疼痛、关节压痛、关节肿胀、关节僵硬和活动不利评分均低于对照组，主要临床症状消失率均低于对照组（P<0.05，P<0.01）；观察组患者DAS28，SDAI，HAQ评分及ESR和CRP水平均低于对照组（P<0.01）；观察组RF，IL-1，IL-6和TNF-α水平均低于对照组（P<0.01）；经Ridit分析，两组患者皮肤刺激反应差异无统计学意义；治疗过程中，观察组患者未发现有关川乌和马钱子的过敏反应和毒副反应。结论：采用复方乌头微乳剂治疗活动期RA患者，能明显控制临床症状和疾病的发展，减轻急性炎症反应，缓解临床疗效，且安全，但临床使用仍需严密观察不良反应。

Abstract

Objective: To discuss the clinical efficacy of fufang Wutou microemulsion in treating rheumatoid arthritis (RA) at active stage and its effect on levels of serum C-reactive protein (CRP)

tumor necrosis factor-α(TNF-α)

interleukin-1 (IL-1) and interleukin-6 (IL-6). Method: Totally 120 patients with HDD were randomly divided into control group (60 cases) and observation group (60 cases) by random number table. Both groups' patients got meloxicam tablets

7.5 mg/time

1 time/day. And glycosides of Baishao capsules

2 grains/day

3 times/day. Patients in control group were also given diclofenac diethylamine emulgel according to the area of painful place

3 times/day. And observation group was also given fufang Wutou microemulsion according to the area of painful place

3 times/day. And a course of treatment was 4 weeks. Before and after treatment

scores of arthralgia

tender joint

swelling

joint stiffness and difficulties in joint activity were recorded. And scores of degree of disease activity (DAS28 scale)

simplified disease activity index (SDAI) and health assessment questionnaire (HAQ) were graded. Levels of erythrocyte sedimentation rate (ESR)

CRP

rheumatoid factors (RF)

TNF-α

IL-1 and IL-6 were detected. And the safety was evaluated. Result: ACR20 and ACR50 in observation group were 91.67% and 56.67%

which were higher than 68.33% and 36.67% in control group (P<0.05

P<0.01)

with no statistical significance in ACR70 between two groups. Scores of arthralgia

tender joint

swelling

joint stiffness and difficulties in joint activity were lower than those in control group

and the disappearance rate of main symptoms was also lower than that in control group (P<0.05

P<0.01). Sores of DAS28

SDAI and HAQ and levels of ESR

CRP

IL-1

IL-6 and TNF-α were lower than those in control group (P<0.01). By Ridit

there was no statistical significance in skin irritation between two groups. And no side effect caused by Chuanwu or Maqianzi was found. Conclusion: Fufang Wutou microemulsion can control clinical symptoms and disease development

relieve acute inflammatory reaction

with an obvious clinical effect and safety

but its adverse reactions shall be observed carefully.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Efficacy of Zhuyuwan in Treatment of Hyperlipidemia with Syndrome of Phlegm Turbidity and Obstruction

Yijingtang Reduces Ovarian Inflammatory Responses in Rat Model of Diminished Ovarian Reserve via TLR4/MyD88/NF-κB Signaling Pathway

Clinical Safety Monitoring of 3 035 Cases of Juvenile Feilike Mixture After Marketing in Hospital

Mechanism of Shengmai Injection Against Cerebral Ischemia Based on Proteomics

Research Advances on Anti-inflammatory and Anti-oxidation Effect of Medicinal and Edible Herbs Liver-protecting Chinese Medicine

Related Author

YANG Lele

LUO Danmei

CHEN Jiao

ZHANG Xiaobo

SONG Wei

ZHU Wenyu

ZHOU Xin

LI Xueping

Related Institution

Hospital of Chengdu University of Traditional Chinese Medicine （TCM）

Chengdu University of TCM

The First Clinical Medical School of Anhui University of Chinese Medicine

The First Affiliated Hospital of Anhui University of Chinese Medicine

Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰