Stability of Rhubarb Anthraquinones in Gastric Juice and Analysis of Synergistic Effect of Its Enteric Preparation

LI Jing; JIN Peng; LIU Xi-gang; LIU Cui-zhe

doi:10.13422/j.cnki.syfjx.20180905

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Stability of Rhubarb Anthraquinones in Gastric Juice and Analysis of Synergistic Effect of Its Enteric Preparation

更新时间：2024-01-04

- Stability of Rhubarb Anthraquinones in Gastric Juice and Analysis of Synergistic Effect of Its Enteric Preparation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 10, Pages: 21-26(2018)
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- DOI：10.13422/j.cnki.syfjx.20180905
  CLC： R285
- Published：2018
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LI Jing, JIN Peng, LIU Xi-gang, et al. Stability of Rhubarb Anthraquinones in Gastric Juice and Analysis of Synergistic Effect of Its Enteric Preparation[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(10): 21-26.
DOI：

LI Jing, JIN Peng, LIU Xi-gang, et al. Stability of Rhubarb Anthraquinones in Gastric Juice and Analysis of Synergistic Effect of Its Enteric Preparation[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(10): 21-26. DOI： 10.13422/j.cnki.syfjx.20180905.

摘要

目的：研究大黄蒽醌类成分在人工胃液中的稳定性，并分析其肠溶化增效作用，为大黄的合理应用提供参考。方法：将大黄水煎液置于人工胃液中，于0.5，1，2 h取样检测大黄蒽醌的含量变化。将大黄提取后喷雾干燥，制备大黄肠溶颗粒，比较其与大黄普通颗粒的泻下作用。结果：大黄药液在胃液中2 h后，游离蒽醌增加了约6.902 mg，结合蒽醌破坏了约23.868 mg，总蒽醌降低了约16.966 mg，发挥泻下作用的结合蒽醌质量下降超过了25%。将大黄制备肠溶颗粒后，同等剂量下，与大黄普通颗粒组相比，大黄肠溶颗粒组12 h内排便总量明显较高。结论：大黄蒽醌类成分在胃液中不稳定，尤其是结合蒽醌水解破坏明显，将大黄制成肠溶剂型可以避免此类成分在胃中被破坏，进而增强药物的泻下作用。

Abstract

Objective: In this study

we researched the stability of rhubarb anthraquinones in artificial gastric juice and synergistic effect of its enteric preparation

in order to provide reference for rational application of Rhei Radix et Rhizoma. Method: Water decoction of Rhei Radix et Rhizoma was placed in the artificial gastric juice

and the content of rhubarb anthraquinones was analysed at 0.5

2 h

respectively.After decoction of Rhei Radix et Rhizoma

rhubarb traditional granules and enteric granules were prepared by spray drying

and then we compared their differences in efficacy of purgaion. Result: After 2 h when water decoction of Rhei Radix et Rhizoma placed in the artificial gastric juice

the content of Rhubarb combined anthraquinones destroyed about 23.868 mg

and the content of total anthraquinones destroyed about 16.966 mg

the content of free anthraquinones increased by about 6.902 mg;the content of combined anthraquinones with purgative effect decreased by about 25%.Compared with the same dose of rhubarb traditional granules group

the defecation volume of rhubarb enteric granules group in 12 h was significantly increased. Conclusion: Rhubarb anthraquinones is unstable in the gastric juice

especially the combined anthraquinones.Rhubarb enteric preparation can avoid anthraquinones being hydrolyzed in the stomach

and enhance its purgative effect.

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