Antibacterial and Anti-inflammatory Effect of Crude Extract of Two  Plants

CHEN Si-si; SHI Xin-hong

doi:10.13422/j.cnki.syfjx.20180940

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Antibacterial and Anti-inflammatory Effect of Crude Extract of Two Plants

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- Antibacterial and Anti-inflammatory Effect of Crude Extract of Two Plants
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 12, Pages: 157-162(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20180940
  CLC： R285.5
- Published：2018
- 稿件说明：
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CHEN Si-si, SHI Xin-hong. Antibacterial and Anti-inflammatory Effect of Crude Extract of Two Plants[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(12): 157-162.
DOI：

CHEN Si-si, SHI Xin-hong. Antibacterial and Anti-inflammatory Effect of Crude Extract of Two Plants[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(12): 157-162. DOI： 10.13422/j.cnki.syfjx.20180940.

摘要

目的：研究斜叶黄檀和两粤黄檀2种植物粗提物的抑菌和抗炎作用。方法：通过二倍稀释法，考察2种植物粗提物对表皮葡萄球菌、痤疮丙酸杆菌和金黄色葡萄球菌的抑菌作用；将小鼠随机分为空白组、阳性组、斜叶黄檀和两粤黄檀低、中、高剂量组（0.85，1.7，2.6 g·kg-1），共8组，每组8只，采用二甲苯致耳肿胀、鸡蛋清致足肿胀和小鼠痤疮模型研究2种黄檀属植物粗提物的抗炎作用。结果： 2种黄檀属植物对表皮葡萄球菌、痤疮丙酸杆菌和金黄色葡萄球菌均有抑菌作用，两粤黄檀的最小抑菌浓度（minimum inhibitory concentration，MIC）分别为5，10，40 g·L-1，斜叶黄檀的MIC分别为2.5，2.5，20 g·L-1。2种黄檀属植物的中、高剂量组均能显著减轻二甲苯所致的小鼠耳肿胀度（P<0.05，P<0.01）；斜叶黄檀高剂量组和两粤黄檀中、高剂量组可明显抑制由鸡蛋清致炎3，4，6 h后的足肿胀度（P<0.01）；斜叶黄檀中剂量组和两粤黄檀中、高剂量组可明显减轻混合菌液引起的耳肿胀度（P<0.01）。结论：斜叶黄檀和两粤黄檀均具有显著的抑菌和抗炎作用。

Abstract

Objective: To study the antibacterial and anti-inflammatory effects of crude extract of Dalbergia pinnata and D. benthamii

two kinds of Dalbergia plants. Method: Two fold dilution method was used to investigate the antimicrobial activity of crude extracts from two plants against Staphylococcus epidermidis

Propionibacterium acnes and S. aureus. Mice were divided into 8 groups randomly

including blank group

positive group

D. benthamii and D. pinnata low dose group

middle dose group and high dose group (0.85

1.7

2.6 g·kg-1)

8 rats in each group. Ear swelling induced by dimethylbenzene

paw swelling induced by egg white and acne model in mice were used to investigate the anti-inflammatory effect of crude extract of two Dalbergia plants. Result: Two Dalbergia plants had antibacterial effects against S. epidermidis

P. acnes

and S. aureus

with minimum inhibitory concentration (MIC) of 5

40 g·L-1 for D. benthamii were and 2.5

2.5

20 g·L-1 for D. pinnata respectively. The middle and high dose of two Dalbergia plants could significantly relieve ear-swelling caused by dimethylbenzene in mice (P<0.05

P<0.01). The high dose of D. pinnata and the middle and high dose of D. benthamii could significantly inhibit paw swelling induced by egg white within 3

6 hours (P<0.01). The middle dose of D. pinnata and the high and middle dose of D. benthamii could significantly alleviate ear swelling induced by mixed bacteria solution (P<0.01). Conclusion: Both D. pinnata and D. benthamii have significant antibacterial and anti-inflammatory effects.

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