Effect of Yupingfeng San Combined with Governor Meridian Long-snake Moxibustion on Serum IL-6, cAMP, cGMP in Patients with Allergic Rhinitis

LI Yong-wen; SUN Mai-qing

doi:10.13422/j.cnki.syfjx.20181031

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Effect of Yupingfeng San Combined with Governor Meridian Long-snake Moxibustion on Serum IL-6, cAMP, cGMP in Patients with Allergic Rhinitis

更新时间：2024-01-04

- Effect of Yupingfeng San Combined with Governor Meridian Long-snake Moxibustion on Serum IL-6, cAMP, cGMP in Patients with Allergic Rhinitis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 11, Pages: 163-167(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20181031
  CLC： R276.1
- Published：2018
- 稿件说明：
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LI Yong-wen, SUN Mai-qing. Effect of Yupingfeng San Combined with Governor Meridian Long-snake Moxibustion on Serum IL-6, cAMP, cGMP in Patients with Allergic Rhinitis[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(11): 163-167.
DOI：

LI Yong-wen, SUN Mai-qing. Effect of Yupingfeng San Combined with Governor Meridian Long-snake Moxibustion on Serum IL-6, cAMP, cGMP in Patients with Allergic Rhinitis[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(11): 163-167. DOI： 10.13422/j.cnki.syfjx.20181031.

摘要

目的：探讨玉屏风散联合督脉铺灸对变应性鼻炎（AR）患者血清白细胞介素-6（IL-6），环磷酸腺苷（cAMP），环磷酸鸟苷（cGMP）的影响。方法：选取2013年6月至2016年6月河南省中医院收治的AR患者100例，依据治疗方法分为铺灸组和玉屏风组，每组50例，铺灸组患者给予西替利嗪+督脉铺灸治疗，玉屏风组患者在此基础上给予玉屏风颗粒治疗，采用酶联免疫吸附法检测血清IL-6，cGMP，cAMP水平，分析所有患者治疗前后血清IL-6，cGMP，cAMP水平和喷嚏、流涕、鼻塞、鼻痒消失时间及治疗疗效、不良反应、复发等情况。结果：铺灸组和玉屏风组治疗后血清IL-6，cGMP，cAMP水平明显低于本组治疗前，玉屏风组治疗后血清IL-6，cGMP水平明显低于铺灸组，玉屏风组治疗后血清cAMP水平明显高于铺灸组（P<0.05）；玉屏风组喷嚏、流涕、鼻塞、鼻痒消失时间明显低于铺灸组，玉屏风组治疗有效率明显高于铺灸组（P<0.05），两组均无严重不良反应发生；随访1年期间，玉屏风组复发率明显低于铺灸组（P<0.05）。结论：玉屏风颗粒联合督脉铺灸治疗可有效提高AR患者的近远期疗效，可能与其更有效调节机体免疫功能平衡有关，且其具有良好的安全性，值得临床作进一步推广。

Abstract

Objective: To discuss the effect of Yupingfeng San combined with governor meridian long-snake moxibustion on serum interleukin-6 (IL-6)

cyclic adenosine monophosphate (cAMP)

cyclic guanosine monophosphate (cGMP) in patients with allergic rhinitis (AR). Method: A total of 100 patients with AR treated from June 2013 to June 2016 in Henan Province Hospital of Traditional Chinese Medicine were selected. According to the treatment method

all of the patients were divided into long-snake moxibustion group and Yupingfeng group

with 50 cases in each group.Long-snake moxibustion group was given cetirizine + governor vessel long-snake moxibustion treatment

Yupingfeng group on the basis was given Yupingfeng granules treatment

Serum IL-6

cGMP

cAMP levels were detected by enzyme-linked immunosorbent method. Before and after treatment

serum IL-6

cGMP

cAMP levels

sneezing

runny nose

stuffy nose

nasal itching disappearance time

efficacy

adverse reaction

recurrence of all of the patients were analyzed. Result: After treatment

serum IL-6

cGMP levels of Yupingfeng San group and long-snake moxibustion group were significantly lower than those before treatment; after treatment

serum IL-6

cGMP levels of Yupingfeng group were significantly lower than those of long-snake moxibustion group; after treatment

serum cAMP level of Yupingfeng group was significantly higher than that of long-snake moxibustion group

with statistically significant differences (P<0.05). Sneezing

runny nose

stuffy nose

nasal itching disappearance time of Yupingfeng group were significantly lower than those of long-snake moxibustion group; therapeutic response rate of Yupingfeng group was significantly higher than that of long-snake moxibustion group

with statistically significant differences (P<0.05) but no serious adverse reaction in the two groups. The recurrence rate of Yupingfeng San group was significantly lower than that of long-snake moxibustion group

with statistically significant differences (P<0.05). Conclusion: Yupingfeng San combined with governor meridian long-snake moxibustion can effectively improve the short-term and long-term efficacy of patients with AR

which may be related to more effective regulation of body immune function. It has a good safety

and is worth further clinical promotion.

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Related Institution

蚌埠医学院第二附属医院

安徽医科大学

School of Traditional Chinese Medicine， Beijing University of Chinese Medicine

Henan Province Hospital of Traditional Chinese Medicine

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