Pancreatic cancer is a malignant tumor of the digestive tract. However

its mechanism is not fully understood because of the multidrug resistance of tumor cells. In order to solve the drug resistance problem

scientists are committed to developing new chemotherapeutic methods. With the development of science and technology

more and more scientific and technological means are expected to provide brand-new treatment methods for treating pancreatic cancer. However

it still takes time from the successful development to clinical application

and the current problem of pancreatic cancer treatment still cannot be solved. Therefore

it is necessary to solve the drug resistance in the clinical treatment of pancreatic cancer at this stage. With the continuous improvement of China's international influence

the traditional Chinese culture has also drawn more and more attention. It is worth mentioning that in recent years

the government has attached more importance to the culture of traditional Chinese medicine and made increasing efforts in driving it. Chinese herbal medicine has been a valuable legacy for Chinese people to struggle with diseases

with a long history and low toxic and side effects

and more affordable by patients. In recent years

it has been reported in the literatures that Chinese herbal medicine compounds have a significant effect in inhibiting the proliferation of tumor cells and can even reverse the drug resistance of tumor cells. Clinical studies have also found that Chinese herbal medicine has a better therapeutic effect on tumor treatment. So far

the literatures on the effect of traditional Chinese medicines(TCM) in reversing the drug resistance of pancreatic cancer in recent years cannot reflect the advance of studies in the field. In this paper

the mechanism of drug resistance in the abnormal expression of pancreatic cancer drug resistance

and the effects of anti-tetrandrine

emodin

astaxanthin

curcumin and other TCM in reversing the progress of tumor drug resistance were reviewed.