Effect and Mechanism of Jianwei Xiaopi Decoction on Disease Prognosis and Development of Patients with Precancerous Lesion of Gastric Cancer

ZHOU Liang; DENG Li-ya; GUO Ling-fei; LI Jin-cun

doi:10.13422/j.cnki.syfjx.20181043

您当前的位置：

首页 >

文章列表页 >

Effect and Mechanism of Jianwei Xiaopi Decoction on Disease Prognosis and Development of Patients with Precancerous Lesion of Gastric Cancer

更新时间：2024-01-04

- Effect and Mechanism of Jianwei Xiaopi Decoction on Disease Prognosis and Development of Patients with Precancerous Lesion of Gastric Cancer
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 10, Pages: 206-211(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20181043
  CLC： R259
- Published：2018
- 稿件说明：
移动端阅览
ZHOU Liang, DENG Li-ya, GUO Ling-fei, et al. Effect and Mechanism of Jianwei Xiaopi Decoction on Disease Prognosis and Development of Patients with Precancerous Lesion of Gastric Cancer[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(10): 206-211.
DOI：

ZHOU Liang, DENG Li-ya, GUO Ling-fei, et al. Effect and Mechanism of Jianwei Xiaopi Decoction on Disease Prognosis and Development of Patients with Precancerous Lesion of Gastric Cancer[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(10): 206-211. DOI： 10.13422/j.cnki.syfjx.20181043.

摘要

目的：观察健胃消痞汤治疗胃癌前病变（PLGC）的临床疗效及对胃泌素17，血清胃蛋白酶原、炎症因子水平和胃黏膜组织环氧合酶-2（COX-2）蛋白表达的影响。方法：将140例符合患者，以SAS软件生成的，随机按数字表法分为对照组和观察组各70例。两组患者均给予导入期治疗，包括给予抑酸、黏膜保护剂、促动力剂、助消化药等对症处理；导入期结束后给予叶酸片，10 mg/次，3次/d，饭前15 min服用。对照组服用温胃舒胶囊，3粒/次，3次/d。观察组采用健胃消痞汤，每天1剂，两组疗程均为连续治疗4个月。两组患者临床进行治疗前后主要症状评分，检查两组患者治疗前后胃镜和胃黏膜组织病理变化，检测治疗前后胃泌素17（G17），血清胃蛋白酶原（PGⅠ和PGⅡ），白细胞介素-1β（IL-1β），肿瘤坏死因子-α（TNF-α），干扰素-γ（IFN-γ）水平和COX-2蛋白表达。结果：两组患者治疗后各项指标均有降低；观察组临床疗效总有效率为91.04%，高于对照组的76.92%（χ2＝4.919，P<0.05）；治疗后观察组胃镜下黏膜病变积分低于对照组（P<0.01）；观察组治疗后上腹疼痛、饱胀、痞闷、嗳气、纳差评分均低于对照组（P<0.01）；治疗后观察组黏膜炎症、腺体减少/萎缩和肠上皮化生评分均低于对照组（P<0.01），COX-2蛋白阳性表达低于对照组（P<0.01）；治疗后观察组患者清G17，PGⅠ水平均高于对照组（P<0.01），PGⅠ/PGⅡ也高于对照组（P<0.01）；治疗后观察组患者IL-1β和TNF-α水平均低于对照组，IFN-γ水平高于对照组（P<0.01）。结论：健胃消痞汤能减轻PLGC临床症状和萎缩程度，对肠上皮化生（IM），异型增生（Dys）有一定的阻断或逆转作用；并能提高G17，PGⅠ水平和PGⅠ/PGⅡ比值，抑制COX-2蛋白表达，调节IL-1β，TNF-α，IFN-γ炎症因子水平。

Abstract

Objective: To observe the clinical efficacy of Jianwei Xiaopi decoction on precancerous lesion of gastric cancer (PLGC) and its effect on levels of gastrin 17

serum pepsinogen

inflammatory factors

and expression of cyclooxygenase in gastric mucosa-2 (COX-2). Method: One hundred and forty patients were randomly divided into control group and observation group by random number table. Both groups' patients got the introduction-stage treatment

including acid suppression

mucosal protective agent

accelerator and digestant. After the introduction stage

folic acid tablets were given 15 min before dinner

10 mg/time

3 times/days. Patients in control group got Wenweishu capsule

3 capsules/time

3 times/day. And Jianwei Xiaopi decoction was given to patients in observation

2 times/dose

1 dose/day. A course of treatment was 4 months. Before and after treatment

main symptoms were scored

gastroscopic and pathological changes of gastric mucosa were detected

and levels of gastrin 17 (G17)

serum pepsinogen (PGⅠand PGⅡ)

interleukin-1β (IL-1β)

tumor necrosis factor-α (TNF-α)

interferon-γ (IFN-γ) and expression of COX-2 were measured. Result: The total effect rate in observation group was 91.04%

which was higher than 76.92% in control group (χ2=4.919

P<0.05). After treatment

score of mucosal lesions detected by gastroscope in observation group was lower than that in control group (P<0.01). Scores of upper abdominal pain

fullness

blocks and chest pressure

belching and poor appetite in observation group were all lower than those in control group (P<0.01). Scores of mucosal inflammation

glandular reduction or atrophy and intestinal metaplasia in observation group were all lower than those in control group (P<0.01). And positive expression of COX-2 in observation group was weaker than that in control group (P<0.01). And G17

PGⅠ and PGⅠ/PGⅡ and IFN-γ in observation group were higher than those in control group (P<0.01). After treatment

IL-1β and TNF-α in observation group were lower than those in control group (P<0.01). Conclusion: Jianwei Xiaopi decoction can relieve clinical symptoms of PLGC and atrophy degree

interdict or reverse IM and Dys

improve levels of G17

PGⅠand PGⅠ/PGⅡ

inhibit expression of COX-2

and regulate levels of IL-1β

TNF-α and IFN-γ.

关键词

Keywords

references

Views

190

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Protective Effect against Helicobacter pylor Gastritis in Mice by Flavonoid Combinations of Alpiniae Officinarum Rhizoma via Inhibition of PI3K/Akt Pathway

Protective Effect of Taohong Siwutang on Cerebral Ischemia-reperfusion Injury Based on A1/A2 Phenotype Transformation of Astrocytes Mediated by JAK2/STAT3 Pathway

Effect of Coptisine on PI3K/Akt/mTOR Signaling Pathway in Chronic Atrophic Gastritis Rats

Influence of Guizhi Jia Longgu Mulitang on Expression of IL-10 and TNF-α in Insomnia Rats with Sensory Dysfunction Dominated by Lung

Improvement of Skin Barrier and Anti-inflammatory Mechanism of Huangliansan on Atopic Dermatitis in Mice

Related Author

LUO Xin

ZHENG Wuyinxiao

YANG Jingyu

ZHAN Jianting

MA Haoran

YE Xiaochuan

GAN Guopin

LIU Dan

Related Institution

Hubei Engineering Research Center for Traditional Chinese Medicine Processing

Hubei Key Laboratory of Resource and Chemistry of Chinese Medicine，School of Pharmacy， Hubei University of Chinese Medicine

School of Pharmacy，Anhui University of Chinese Medicine

MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials

Anhui Province Key Laboratory of Chinese Medicinal Formula

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰