Objective: To evaluate the intervention effect of different processed products of Bupleuri Radix on heat-induced deficiency heat syndrome rats. Method: Totally 46 healthy male rats were randomly divided into two groups:normal group (6 rats)

and model group (40 rats). The model group was intragastrically administered with intragastrically Aconiti Lateralis Radix Praeparata

Zingiberis Rhizoma and Cinnamomi Cortex (20 g·kg-1) to establish the internal heat model. After the successful modeling

they were randomly divided into normal group

model group

positive group (Zhibai Dihuangwan

0.5 g·kg-1)

raw Bupleuri Radix group

Turtle blood Bupleuri Radix group

turtle blood combined with Bupleuri Radix group

wine Bupleuri Radix group

and vinegar Bupleuri Radix group. The dosage of each processed product was 3.15 g·kg-1. In the normal group

rats were administered with the same amount of double-distilled water once a day for 11 days. The general conditions and metabolic cage index of rats were measured

and the radix bupleuri basal metabolic changes

D-xylose in serum

triiodothy ronine (T3)

thy roxine (T4)

cAMP

cGMP content

cortisol

lactic acid (LD)

lactate dehydrogenase (LDH)

activity of adenosine triphosphate(ATP) enzyme content and organ indexes of rats were compared. Result: Compared with the normal group

the body weight of rats in the model group increased slowly

the rectal temperature

water intake

urine volume and body fluid consumption elevated

and food intake and D-xylose content decreased; cAMP

cGMP content

LD in serum

LDH activity

adenosine triphosphate activity

T3 and T4 content increased (P<0.05). This indicated that the internal heat model was successfully established (P<0.05). Compared with the model group

the D-xylose in different processed product groups and positive drug group increased (P<0.05); the levels of cAMP and cGMP decreased (P<0.05); the levels of lactate and lactate dehydrogenase increase and the levels of ATP

T3

T4 in each group decreased (P<0.05). Conclusion: Bupleuri Radix's different processed products can make the physiological indicators of the internal heat induced by traditional Chinese medicine in rats to return to normal

indicating a therapeutic effect on the internal heat syndrome in rats. However

the effects of different processed products vary on different physiological indexes. Therefore

different processed products have different degrees of intervention on the internal heat of rats.