Effect of Ultra-filtration Extraction from Angelicae Sinensis Radix and Hedysari Radix on Cell Proliferation and Collagen Secretion of Myocardial Fibroblasts Induced by Radiation
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Effect of Ultra-filtration Extraction from Angelicae Sinensis Radix and Hedysari Radix on Cell Proliferation and Collagen Secretion of Myocardial Fibroblasts Induced by Radiation
Chinese Journal of Experimental Traditional Medical FormulaeVol. 24, Issue 12, Pages: 136-142(2018)
YANG Yi-xuan, ZHANG Zhao-fang, LIU Hiu, et al. Effect of Ultra-filtration Extraction from Angelicae Sinensis Radix and Hedysari Radix on Cell Proliferation and Collagen Secretion of Myocardial Fibroblasts Induced by Radiation[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(12): 136-142.
DOI:
YANG Yi-xuan, ZHANG Zhao-fang, LIU Hiu, et al. Effect of Ultra-filtration Extraction from Angelicae Sinensis Radix and Hedysari Radix on Cell Proliferation and Collagen Secretion of Myocardial Fibroblasts Induced by Radiation[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(12): 136-142. DOI: 10.13422/j.cnki.syfjx.20181050.
Effect of Ultra-filtration Extraction from Angelicae Sinensis Radix and Hedysari Radix on Cell Proliferation and Collagen Secretion of Myocardial Fibroblasts Induced by Radiation
Objective: To investigate the effect of ultra-filtration extraction from Angelicae Sinensis Radix and Hedysari Radix on the cell proliferation and collagen deposition of myocardial fibroblasts induced by radiation. Method: Rat myocardial fibroblasts were separated and cultured by cell adhesion. The cell proliferation was determined by thiazolyl blue tetrazolium bromide (MTT) method
and the collagen- Ⅰ (COL- Ⅰ) of secretion was determined by enzyme-linked immuno sorbent assay (ELISA) method after ultra-filtration extraction from Angelicae Sinensis Radix and Hedysari Radix or radiation to myocardial fibroblasts. The changes of reactive oxygen species (ROS) were determined by flow cytometry with indicator 2'
7'-dichloride fluorescent yellow double acetate (DCFH-DA) staining. The mRNA expressions of COL- Ⅰ and transforming growth factor-beta (TGF-β) were determined by Real-time polymerase chain reaction (PCR)
and the expressions of relative proteins were determined by Western blot. Result: The rising cellular ROS promoted cell proliferation and collagen deposition of myocardial fibroblasts induced by low-dose radiation (0.5 Gy)
which however was inhibited through ultra-filtration extraction from Angelicae Sinensis Radix and Hedysari Radix by promoting nuclear translocation of nuclear factor E2 related factor 2 (Nrf2) and eliminating ROS. The mRNA expressions of COL- Ⅰ and TGF-β were both inhibited by ultra-filtration extraction from Angelicae Sinensis Radix and Hedysari Radix. Conclusion: Ultra-filtration extraction from Angelicae Sinensis Radix and Hedysari Radix could inhibit the cell proliferation and collagen deposition of myocardial fibroblasts induced by low-dose radiation.
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