GAO Ling, SU Li, YANG Ting, et al. Cardioprotective Effect of Qiangxin Huoli Recipe on Adriamycin-induced Cardiotoxicity[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(14): 153-158.
DOI:
GAO Ling, SU Li, YANG Ting, et al. Cardioprotective Effect of Qiangxin Huoli Recipe on Adriamycin-induced Cardiotoxicity[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(14): 153-158. DOI: 10.13422/j.cnki.syfjx.20181051.
Cardioprotective Effect of Qiangxin Huoli Recipe on Adriamycin-induced Cardiotoxicity
Objective: To study the intervention effect of Qiangxin Huoli recipe on cardiotoxicity after chemotherapy of antitumor drug ADR in rats. Method: Totally 96 healthy Wistar rats were randomly divided into 6 groups
namely normal group
ADR model group (16 mg·kg-1)
Shenfu control group (3 g·kg-1)
and high-dose
medium-dose
low-dose Qiangxin Huoli recipe groups (3.6
1.8
0.9 g·kg-1). The mental state
eating
feces and fur of each group of rats were observed. After 24 h of the last intragastric administration
plasma brain natriuretic peptide (BNP) levels
electrocardiogram (ECG)
whole heart mass index (HW/BW)
hematoxylin-eosin staining (HE) staining
Masson staining and transmission electron microscopy (TEM) were detected
and the myocardial morphological and ultrastructural changes were observed. Result: Compared with normal group
the ADR model group had significant differences from normal control rats (P<0.05
P<0.01) in weight loss; ECG showed significantly abnormal changes; plasma BNP and HW/BW significantly increased. Myocardial and ultrastructure injury were observed by light microscope and sem. Qiangxin Huoli recipe can obviously improve the general conditions and body quality of rats
decrease the plasma BNP levels and HW/BW
reverse the abnormal ECG
and inhibit the myocardial fibrosis
cellular edema and abnormal changes of ultrastructure
especially in the high-dose group. The differences from ADR group were quite obvious (P<0.05
P<0.01). Conclusion: Qiangxin Huoli recipe has a protective effect on adriamycin-induced cardiotoxicity in rats.
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Related Author
CHEN Yin-fang
YU Ri-yue
XIONG Yao-kun
XU Guo-liang
ZHANG Kai
NIE Bin
YAN Xiao-jun
LIU Hong-ning
Related Institution
Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention
Huangshi Central Hospital/Affiliated Hospital of Hubei Polytechnic University
Anhui Province Key Laboratory of Chinese Medicinal Formula
Anhui University of Chinese Medicine
Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation