Efficacy of Duhuo Jisheng Tang Combined with Warm Acupuncture in Treating Patients with Wind-cold Dampness-type Knee Osteoarthritis and Effect on Serum Pain Mediators, Inflammatory Mediators and Leukotrienes

ZHANG Qi-zhen; MIAO Yu; WANG Da-li; CHEN Shao-qing; LI Hua-nan

doi:10.13422/j.cnki.syfjx.20181321

您当前的位置：

首页 >

文章列表页 >

Efficacy of Duhuo Jisheng Tang Combined with Warm Acupuncture in Treating Patients with Wind-cold Dampness-type Knee Osteoarthritis and Effect on Serum Pain Mediators, Inflammatory Mediators and Leukotrienes

更新时间：2024-01-04

- Efficacy of Duhuo Jisheng Tang Combined with Warm Acupuncture in Treating Patients with Wind-cold Dampness-type Knee Osteoarthritis and Effect on Serum Pain Mediators, Inflammatory Mediators and Leukotrienes
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 18, Pages: 153-158(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20181321
  CLC： R259
- Published：2018
- 稿件说明：
移动端阅览
ZHANG Qi-zhen, MIAO Yu, WANG Da-li, et al. Efficacy of Duhuo Jisheng Tang Combined with Warm Acupuncture in Treating Patients with Wind-cold Dampness-type Knee Osteoarthritis and Effect on Serum Pain Mediators, Inflammatory Mediators and Leukotrienes[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(18): 153-158.
DOI：

ZHANG Qi-zhen, MIAO Yu, WANG Da-li, et al. Efficacy of Duhuo Jisheng Tang Combined with Warm Acupuncture in Treating Patients with Wind-cold Dampness-type Knee Osteoarthritis and Effect on Serum Pain Mediators, Inflammatory Mediators and Leukotrienes[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(18): 153-158. DOI： 10.13422/j.cnki.syfjx.20181321.

摘要

目的：观察独活寄生汤配合温针灸治疗风寒湿痹型膝骨关节炎（KOA）膝关节疗效及对血清疼痛介质、炎症介质、白三烯（LT）的影响。方法：将94例风寒湿痹型KOA患者随机分为对照组（30例），独活寄生汤组（34例）及联合组（30例），对照组给与硫酸氨基葡萄糖胶囊0.5 g/次，3次/d口服；独活寄生汤组给予独活寄生汤150 mL，2次/d口服；联合组在独活寄生汤组治疗基础上给予温针灸治疗，疗程均为4周；观察入组患者治疗前后膝关节视觉模拟评分（VAS），自制膝关节肿胀评分及总有效率变化；酶联免疫吸附法（ELISA）检测各组患者血清中疼痛介质[前列腺素E2（PGE2），P物质（SP），多巴胺（DA），五羟色胺（5-HT）]，炎症介质[肿瘤坏死因子-α（TNF-α），白细胞介素-1β（IL-1β）]及白三烯B4，白三烯C4，白三烯D4（LTB4，LTC4，LTD4）的表达。结果：治疗后联合组VAS，膝关节肿胀评分及对KOA疼痛疗效明显高于对照组和独活寄生汤组（P<0.05）；与对照组治疗后相比，独活寄生汤组及联合组患者血清PGE2，SP，DA，5-HT，TNF-α，IL-1β，LTB4，LTC4，LTD4含量降低（P<0.05），与独活寄生汤组治疗后相比，联合组患者血清PGE2，SP，DA，5-HT，TNF-α，IL-1β，LTB4，LTC4，LTD4含量降低趋势更加明显（P<0.05）。结论：独活寄生汤配合温针灸可有效治疗风寒湿痹型KOA患者膝关节肿痛，其机制可能与降低LTB4，LTC4，LTD4及炎症介质含量有关。

Abstract

Objective: To observe the efficacy of Duhuo Jisheng Tang combined with warm acupuncture in treating patients with wind-cold dampness-type knee osteoarthritis (KOA) and explore its effect on serum pain mediators

inflammatory mediators and leukotrienes. Method: The 94 patients with wind-cold dampness-type KOA were randomly divided into control group (30 cases)

Duhuo Jisheng Tang group (34 cases)

and the combined group (30 cases). The control group was given with glucosamine sulfate capsules 0.5 g/time

tid by oral administration. The patients in Duhuo Jisheng Tang group received Duhuo Jisheng Tang 150 mL/times

bid by oral administration. And the combined group additionally received warm acupuncture on the basis of Duhuo Jisheng Tang. The course of treatment was 4 weeks in all groups. The knee joint visual analogue scale (VAS)

self-made knee joint swelling score and total effective rate were observed both before and after treatment; enzyme-linked immunosorbent assay (ELISA) was used to detect the serum pain mediators[prostaglandin E2(PGE2)

substance P (SP)

dopamine(DA)

5-hydroxytryptamine(5-HT)]

inflammatory mediators[tumor necrosis factor-α (TNF-α)

interleukin-1β(IL-1β)]and leukotrienes[leukotriene (LT)B4

LTC4

LTD4]in all groups. Result: After treatment

the VAS scores

knee swelling scores and the efficacy for pain in combined group were significantly higher than those in control group and Duhuo Jisheng Tang group (P<0.05). As compared with control group

the levels of serum PGE2

5-HT

TNF-α

IL-1β and allogeneic leukotrienes we lower in the Duhuo Jisheng Tang group and combined group (P<0.05). The decreases in levels of serum PGE2

5-HT

TNF-α

IL-1β

LTB4

LTC4 and LTD4 in combined group were more obvious than those in Duhuo Jisheng Tang group after treatment (P<0.05). Conclusion: Warm acupuncture combined with Duhuo Jisheng Tang could effectively treat the knee joint pain for wind-cold dampness-type KOA

and the mechanism may be related to the reduction of LTB4

LTC4

LTD4 and inflammatory mediators.

关键词

Keywords

references

Views

394

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Duhuo Xuduan Tang for Oral Administration and Iontophoresis on SDF-1/CXCR4 Signaling Pathway and Relevant Factors of Cartilage Degradation in Knee Joint Fluid of Patients with Knee Osteoarthritis with Liver and Kidney Deficiency

Effect of Duhuo Jisheng Tang Combined with Acupuncture in Treatment of Wind Cold Dampness Type Knee Osteoarthritis

Changes of Serum Lysine and -cryptoxanthin in Patients with Hepatorenal Deficiency Type Knee Osteoarthritis Treated with Duhuo Jisheng Tang and Its Correlation with Pain

Characteristics of Traditional Chinese Medicine Syndromes in Patients with Concurrent Postmenopausal Osteoporosis and Knee Osteoarthritis

A Multicenter， Randomized， Double-blind， and Placebo-parallel Controlled Trial of Tibetan Medicine Ruyi Zhenbaowan in Treatment of Knee Osteoarthritis

Related Author

Sheng LIU

Ling LIU

Wei FANG

Xing-hua HAI

KUANG Yao

LI Zheng-fei

SUN Peng

FAN Wei-jun

Related Institution

The Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Tianjin Fourth Central Hospita

Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences

Beijing Electric Power Hospital of State Grid Corporation of China

Wangjing Hospital， China Academy of Chinese Medical Sciences

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰