Colorectal carcinoma is currently one of the most common gastrointestinal cancers

so far

the global incidence is still rising and the patients tend to be younger. As a result

it's urgent in clinical practice to improve the sensitivity of colorectal carcinoma diagnosis

fully understand the etiology and pathogenesis of colorectal carcinoma

and seek for effective treatment and preventative measures. Animal models for colorectal carcinoma can validly simulate the occurrence

development and outcome of colorectal carcinoma

which can be used as one of the most important methods to explore pathogenesis and mechanism of metastasis and simplify the experimental steps and explore the mechanism. Many researches have shown that

the replication of colorectal carcinoma in animals with different genetic backgrounds and the various experimental studies under the artificial control condition are conducive to shortening the experimental periods and observing the whole process of colorectal carcinoma:occurrence

development and outcome. At present

nude mice

mice and rats in the age of 4-6 weeks are often used as model animals. Tumors of zebrafish and human have a high degree of similarity at the histological level. With the development of microsurgery

zebrafish is gradually emerging as a model in the study of oncology. As different model organisms have various biological characteristics

their modeling methods are also different. According to the experimental objectives

periods and techniques

appropriate model organisms and corresponding modeling methods are the key to the success of colorectal carcinoma experiments. Recently

researches about colorectal carcinoma models are constantly springing up

however

the classification is based on modeling methods in most of researches

lacking the exploration of different types of model animals. On the basis of the combination of literature both at home and abroad

this paper provides a review on the nearest decade research progress of different animal models for colorectal carcinoma

and proposes some references for further studies on colorectal carcinoma.