Randomized Control Trial of Modified Dingzhenwan Combined with Acupuncture Method of Consciousness Restoration and Resuscitation in Treating with Patients Parkinson's Disease

HUANG Zong-wen; YUAN Yong; GONG Ai-min; QIU Long

doi:10.13422/j.cnki.syfjx.20181333

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Randomized Control Trial of Modified Dingzhenwan Combined with Acupuncture Method of Consciousness Restoration and Resuscitation in Treating with Patients Parkinson's Disease

更新时间：2024-01-04

- Randomized Control Trial of Modified Dingzhenwan Combined with Acupuncture Method of Consciousness Restoration and Resuscitation in Treating with Patients Parkinson's Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 13, Pages: 190-195(2018)
- 作者机构：
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- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20181333
  CLC： R277.7
- Published：2018
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HUANG Zong-wen, YUAN Yong, GONG Ai-min, et al. Randomized Control Trial of Modified Dingzhenwan Combined with Acupuncture Method of Consciousness Restoration and Resuscitation in Treating with Patients Parkinson's Disease[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(13): 190-195.
DOI：

HUANG Zong-wen, YUAN Yong, GONG Ai-min, et al. Randomized Control Trial of Modified Dingzhenwan Combined with Acupuncture Method of Consciousness Restoration and Resuscitation in Treating with Patients Parkinson's Disease[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(13): 190-195. DOI： 10.13422/j.cnki.syfjx.20181333.

摘要

目的：观察定振丸加减联合醒脑开窍针刺法治疗肝肾阴虚证帕金森病（PD）的疗效，探讨其可能的作用机制。方法：纳入PD患者82例，按随机数字表法分为对照组和治疗组各41例。两组患者均口服多巴丝肼片，0.125 g/次，3次/d。对照组采取醒脑开窍针刺法，1次/d，6次/周。治疗组在对照组治疗的基础上内服定振丸加减治疗，1剂/d。两组连续治疗8周。比较两组颤证功能障碍、肝肾阴虚证症状、帕金森病评定量表（UPDRS），帕金森非运动症状筛查问卷（NMSQuest）评分，帕金森非运动症状评价量表（NMSS）以及临床疗效比较。检测两组血清B淋巴细胞瘤-2（Bcl-2），B细胞淋巴瘤-2相关X蛋白（Bax），细胞色素-C（CytC）以及半胱氨酸天冬氨酸蛋白酶（Caspase）-9，Caspase-3，Caspase-6水平比较。结果：治疗后，治疗组患者颤证功能障碍、肝肾阴虚证症状以及UPDRS-Ⅰ，UPDRS-Ⅱ和UPDRS-Ⅲ评分均明显低于对照组（P<0.01）；与对照组比较，治疗组治疗后NMSQuest和NMSS评分均明显降低（P<0.01）；治疗组的总有效率为87.8%，显著高于对照组总有效率65.85%（P<0.05）；治疗后，治疗组患者血清Bcl-2水平显著高于对照组，Bax，Cytc及Caspase-9，Caspase-3，Caspase-6水平均明显低于对照组（P<0.01）。结论：在西医治疗的基础上，定振丸加减联合醒脑开窍针刺法治疗PD肝肾阴虚证有明显效果，能调节患者体内Bcl-2，Bax，CytC水平，抑制Caspase-9，Caspase-3，Caspase-6水平的表达，从而发挥治疗作用。

Abstract

Objective: To observe the efficacy of modified Dingzhenwan combined with acupuncture method of consciousness restoration and resuscitation in treating patients with Parkinson's disease (PD)

and investigate its possible mechanism. Method: Eighty-two patients with PD were chosen and randomly divided into control group (41 cases) and treatment group (41 cases) referring to random number table. Both groups orally took levodopa/benserazide dispersible tablet

0.125 g/time

tid. The patients in control group were additionally treated with acupuncture method of consciousness restoration and resuscitation

1 time/day and 6 times/week. On basis of the treatment in control group

the patients in treatment group were additionally treated with Dingzhenwan

1 dose/day and bid. Both groups were treated for 8 weeks. Then the scores of dysfunction of tremor syndrome

symptoms of liver and kidney Yin deficiency syndrome

the Unified PD Rating Scale (UPDRS)

non-motor symptoms questionnaire for Parkinson's disease (NMSQuest)

Parkinson's non-motor symptom rating scale (NMSS) and clinical efficacy were compared between two groups. Serum levels of B cell lymphoma/leukemia 2 (Bcl-2)

Bcl-associated X protein (Bax)

cytochrome C (CytC)

Caspase-9

Caspase-3 and Caspase-6 were detected and compared between these two groups. Result: After treatment

the scores of dysfunction of tremor syndrome

symptoms of liver and kidney deficiency syndrome

UPDRS-Ⅰ

UPDRS-Ⅱand UPDRS-Ⅲ in treatment group were significantly lower than those in control group (P<0.01). As compared to the control group

scores of NMSQuest and NMSS were obviously decreased in treatment group after treatment (P<0.01). Total effective rate was 87.8% in treatment group

higher than 65.85% in control group (P<0.05). After treatment

serum level of Bcl-2 in treatment group was significantly higher

while Bax

Cytc

Caspase-9

Caspase-3 and Caspase-6 levels were significantly lower than those in control group (P<0.01). Conclusion: Based on routine western medicine

Dingzhenwan combined with acupuncture method of consciousness restoration and resuscitation has significant efficacy in treating PD

and the mechanism may be associated with regulating Bcl-2

Bax and CytC levels and inhibiting Caspase-9

Caspase-3 and Caspase-6 levels.

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