Objective: To observe the clinical efficacy of modified Buyang Huanwutang combined with scalp acupuncture on unilateral spatial neglect (USN) and its effect on hemorheology. Method: One hundred and twelve patients with USN were divided into control group (56 cases) and observation group (56 cases) according to the order of admission by random number table. Both groups' patients got rehabilitation training and repetitive transcranial magnetic stimulation therapy. Patients in control group got scalp acupuncture

1 time/day

6 times/week. In addition to the therapy for control group

patients in observation group were also given modified Buyang Huanwutang

1 dose/day. The treatment lasted for 8 weeks. The severity of USN was scored by linear scoring test

line deletion test and clock drawing test. Fugl-Meyer scale was used to detect the motor function. Barthel index was used for measuring the ability of daily living. Mini-mental state examination (MMSE) was used for detecting the cognitive function. And Hamilton depression scale (HAMD) and world health organization survival quality assessment scale (WHO-QOL-100) scale were used for measuring depression symptom. Before and after treatment

hemodynamic indexes were detected. Result: After treatment

the scores of linear scoring test

line deletion test and clock drawing task in observation group were lower than those in control group (P<0.01). The scores of upper and lower limbs and the total score of Fugl-Meyer scale in observation group were higher than those in control group (P<0.01). The scores of Barthel and MMSE in observation group were higher than those in control group

but the score of HAMD was lower than that in control group (P<0.01). The cognitive function and activities of daily living in observation group were improved more significantly than those in control group (P<0.05). Five composite scores in WHO-QOL-100 scale

namely physical performance

mental function

independence

social relations

and quality of life

were higher than those in control group (P<0.01). And indicators of hemorheology

such as whole blood viscosity (high and low shearing)

whole blood reduced viscosity

plasma viscosity

fibrinogen

platelet aggregation rate

were all superior to those in control group (P<0.01). Conclusion: Modified Buyang Huanwutang combined with scalp acupuncture can relieve illness degree

improve the cognitive function and hemorheological indicators

reduce depression symptom

improve exercise

self-help ability and quality of life

and thus is worth clinical application.