Analysis on Intestinal Absorption Properties of Total Flavonoids Extract of  Dried Flowers and Its Composite Particles Based on Everted Gut Sac Model

WANG Xiu-mei; LIANG Xin-li; GUAN Yong-mei; WANG Fang; MEI li; LI Yuan-hui; KONG Xiao-qiang; YANG Ming

doi:10.13422/j.cnki.syfjx.20181410

您当前的位置：

首页 >

文章列表页 >

Analysis on Intestinal Absorption Properties of Total Flavonoids Extract of Dried Flowers and Its Composite Particles Based on Everted Gut Sac Model

更新时间：2024-01-04

- Analysis on Intestinal Absorption Properties of Total Flavonoids Extract of Dried Flowers and Its Composite Particles Based on Everted Gut Sac Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 14, Pages: 15-19(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20181410
  CLC： R285
- Published：2018
- 稿件说明：
移动端阅览
WANG Xiu-mei, LIANG Xin-li, GUAN Yong-mei, et al. Analysis on Intestinal Absorption Properties of Total Flavonoids Extract of Dried Flowers and Its Composite Particles Based on Everted Gut Sac Model[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(14): 15-19.
DOI：

WANG Xiu-mei, LIANG Xin-li, GUAN Yong-mei, et al. Analysis on Intestinal Absorption Properties of Total Flavonoids Extract of Dried Flowers and Its Composite Particles Based on Everted Gut Sac Model[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(14): 15-19. DOI： 10.13422/j.cnki.syfjx.20181410.

摘要

目的：考察玉簪花总黄酮提取物及其复合粒子中有效成分的肠吸收特性。方法：采用离体外翻肠囊模型，选择十二指肠、空肠、回肠、结肠为研究肠段，以表观渗透系数为评价参数，考察玉簪花总黄酮提取物及其复合粒子中有效成分山柰酚-3-O-槐糖苷和山柰酚-3-O-芸香糖苷在不同肠段、不同浓度下的肠吸收特性。结果：在不同药物质量浓度下，山柰酚-3-O-槐糖苷及山柰酚-3-O-芸香糖苷在各肠段均有吸收；在同一质量浓度条件下，二者均以空肠的肠吸收最优。结论：玉簪花总黄酮复合粒子改变了山柰酚-3-O-槐糖苷及山柰酚-3-O-芸香糖苷的肠吸收特性，二者在结肠的吸收显著增加。玉簪花总黄酮复合粒子可显著提高该有效部位在结肠部位的吸收。

Abstract

Objective: To investigate intestinal absorption properties of active ingredients in total flavonoids extract of Hosta plantaginea dried flowers and its composite particles. Method: Everted gut sac model was employed.The duodenum

jejunum

ileum and colon of rats were selected as intestinal segment for research.The apparent permeability coefficient(Papp) was used to evaluate the intestinal absorption characteristics of active ingredients from total flavonoids extract of H. plantaginea dried flowers and its composite particles in different intestinal segments and different concentrations. Result: Under different drug concentrations

kaempferol-3-O-sophoroside and kaempferol-3-O-rutinoside were absorbed in all intestinal segments;at the same concentration

their absorption in the jejunum were the best. Conclusion: The composite particles of total flavonoids extract of H. plantaginea dried flowers changes the intestinal absorption characteristics of kaempferol-3-O-sophoroside and kaempferol-3-O-rutinoside

and it can notably enhance their absorption in the colon.The composite particles can significantly increase the absorption of total flavonoids extract of H. plantaginea dried flowers in the colon.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Simultaneous Determination Content of Four Flavonoid Glycosides in Shanlamei Qinggan Cha by HPLC

Effect of Total Flavonoids Extract of on Serum Metabolites in Asthmatic Rat Model

Related Author

BAI Fu-zu

WANG Yun-jie

ZHOU Bin

AYIGU·

Tureke

ABDIRYIM·

Yusup

BATUER·

Related Institution

No data

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰