Effect of Danqi Yishen Prescription on Vascular Endothelial Function and Urinary Insulin-Like Growth Factor of Diabetic Neuropathy with Qi Yin Deficiency and Blood-Stasis Syndrome

LI Jian-ping; ZHANG Yuan-li; MA Yan-hua; ZHU De-li; ZHANG Yu; LIANG Hao

doi:10.13422/j.cnki.syfjx.20181429

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Effect of Danqi Yishen Prescription on Vascular Endothelial Function and Urinary Insulin-Like Growth Factor of Diabetic Neuropathy with Qi Yin Deficiency and Blood-Stasis Syndrome

更新时间：2024-01-04

- Effect of Danqi Yishen Prescription on Vascular Endothelial Function and Urinary Insulin-Like Growth Factor of Diabetic Neuropathy with Qi Yin Deficiency and Blood-Stasis Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 14, Pages: 170-175(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20181429
  CLC： R587.2;R692.9
- Published：2018
- 稿件说明：
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LI Jian-ping, ZHANG Yuan-li, MA Yan-hua, et al. Effect of Danqi Yishen Prescription on Vascular Endothelial Function and Urinary Insulin-Like Growth Factor of Diabetic Neuropathy with Qi Yin Deficiency and Blood-Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(14): 170-175.
DOI：

LI Jian-ping, ZHANG Yuan-li, MA Yan-hua, et al. Effect of Danqi Yishen Prescription on Vascular Endothelial Function and Urinary Insulin-Like Growth Factor of Diabetic Neuropathy with Qi Yin Deficiency and Blood-Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(14): 170-175. DOI： 10.13422/j.cnki.syfjx.20181429.

摘要

目的：观察丹芪益肾方对气阴两虚夹瘀型糖尿病肾病(DN)患者的疗效及对血清凝血酶调节蛋白(TM)，血管性假性血友病因子(vWF)，内皮素(ET)及尿中胰岛素样生长因子(IGF)-1和IGF-2水平的影响。方法：筛选收治的DN患者150例，按数字表法随机分为对照组和治疗组各75例。两组患者参照《糖尿病肾病防治专家共识(2014年版)》给予常规治疗。对照组采用还原型谷胱甘肽静脉滴注，1次/d。治疗组注射西药同对照组，并加服丹芪益肾方，l剂/d，常规水煎煮2次内服。两组患者均连续治疗3个月。比较两组患者血糖和血脂水平、气阴两虚夹瘀证症状评分、肾功能及临床疗效。检测两组患者血清凝血酶调节蛋白(TM)，血管性假性血友病因子(vWF)，内皮素(ET)及尿中胰岛素样生长因子(IGF)-1和IGF-2水平。结果：治疗后，治疗组患者空腹血糖(FPG)，餐后2 h血糖(PPG)，总胆固醇(TC)，甘油三酯(TG)水平及气阴两虚夹瘀证症状评分均明显低于对照组(P<0.01)。治疗后，治疗组患者的肾功能指标血清肌酐(SCr)，血尿素氮(BUN)，24 h尿总蛋白，24 h尿清蛋白及尿β2微球蛋白(β2-MG)水平均明显低于对照组(P < 0.01)。治疗组患者临床总有效率为88％，优于对照组有效率73.33％(P<0.05)。治疗后，治疗组患者血清TM，vWF，ET水平及尿中IGF-1，IGF-2水平均明显低于对照组(P<0.01)。结论：丹芪益肾方配合还原型谷胱甘肽静脉滴注治疗糖尿病肾病，可促进气阴两虚夹瘀证症状及肾功能的改善，提高临床疗效，且可调节患者体内血清和肾功能指标水平，其机制可能是通过抑制TM，vWF，ET，IGF-1和IGF-2释放有关。

Abstract

Objective: To investigate the efficacy of Danqi Yishen prescription on diabetic nephropathy with Qi Yin deficiency and blood-stasis syndrome and the effect on serum levels of thrombin regulating protein (TM)

vascular pseudohemophilia factor (vWF)

endothelin (ET) and urine levels of insulin-like growth factor (IGF)-1 and IGF-2. Method: One hundred fifty cases of diabetic nephropathy were randomly divided into control group (75 cases) and treatment group (75 cases). Both groups received routine treatment by reference to the expert consensus on prevention and control of diabetic nephropathy (2014 edition). Control group was treated with reduced glutathione intravenous drip

qd. In addition of the therapy of control group

treatment group was given Danqi Yishen prescription 1 dose/day. Both groups were treated for 2 months. Blood sugar and lipid levels

symptoms of Qi Yin deficiency and blood-stasis syndrome

kidney function and efficacy were compared between the two groups. Serum levels of TM

vWF

ET and urine levels of IGF-1 and IGF-2 were detected in both groups. Result: After treatment

levels of fasting blood glucose (FPG)

2 h blood glucose (PPG)

total cholesterol (TC)

triglyceride (TG) and scores of symptoms of Qi Yin deficiency and blood-stasis syndrome of treatment group were obviously lower than those of control group (P < 0.01). After treatment

kidney function indexes serum creatinine (SCr)

blood urea nitrogen (BUN)

24 h urinary total protein

24 h urinary albumin and urine β2-microglobulin (β2-MG) were remarkably lower than those of control group (P<0.01). Total effective rate of treatment group was 88%

which was higher than 73.33% of control group (P<0.05). Serum levels of TM

vWF

ET and urine levels of IGF-1 and IGF-2 of treatment group were evidently lower than those of control group (P < 0.01). Conclusion: Danqi Yishen prescription combined with reduced glutathione intravenous drip can alleviate symptoms of Qi Yin deficiency and blood-stasis syndrome

improve clinical efficacy

and regulate kidney function indexes in treating diabetic neuropathy. Its mechanism may be correlated with the release of TM

vWF

IGF-1 and IGF-2.

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