YIN Xiao-yue, WANG Wei-dong, QIAN Chao-ju, et al. Analysis of Metabolomics in Based on UPLC-MS[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(15): 51-56.
DOI:
YIN Xiao-yue, WANG Wei-dong, QIAN Chao-ju, et al. Analysis of Metabolomics in Based on UPLC-MS[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(15): 51-56. DOI: 10.13422/j.cnki.syfjx.20181503.
Objective: To evaluate the potential medicine usage
we aimed to verifying its medicinal active ingredients of Agriophyllum squarrosum. Method: We explored medicinal active ingredients in the above-ground tissues of A. squarrosum based on UPLC-MS non-targeted metabonomics analysis.Quantitative analysis of metabolites was carried out using a multi-reaction monitoring model(MRM) of triple quadrupole mass spectrometry.The multivariate statistical analysis was used to analyze the difference metabolites in the above-ground tissues of A. squarrosum. Result: With metabonomics analysis
a total of 506 metabolites were detected in the above-ground tissues of A. squarrosum
including flavonoids
alkaloids
polyphenols
vitamins
terpenes
amino acids
etc.Most of the active ingredients had a significant concentration in the aerial part of A. squarrosum
though some metabolites concentration differed among tissues.The spikes mainly contained amino acids
while the stems and leaves were rich in the secondary metabolites
including flavonoids
polyphenols
alkaloids
vitamins
etc. Conclusion: A. squarrosum has a variety of potential functions
such as anti-oxidation
anti-tumor
anti-inflammatory
antibacterial
lowering blood pressure
protecting cardiovascular and cerebrovascular
etc.This work supports that it is highly promising to develop new drugs using the above-ground tissues of A. squarrosum.Meanwhile
it also provides important data for A. squarrosum as a new Chinese herbal medicine resource which can play an important role in sustainable ecological agriculture and health industry in arid and semi-arid regions.
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Related Author
LIU Mengmeng
LU Jing
LI Weijia
ZHANG Wenjing
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Related Institution
Changchun University of Chinese Medicine
Affiliated Hospital of Changchun University of Chinese Medicine
Shandong University of Traditional Chinese Medicine(TCM)
Affiliated Hospital of Shandong University of TCM
Institute of Traditional Chinese Medicine, School of Pharmacy, Heilongjiang University of Chinese Medicine