WU Xiao-xia, ZHANG Li-shi, GAO Huan, et al. Antipyretic Mechanism of Guizhitang and Its Effective Components Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(15): 190-197.
DOI:
WU Xiao-xia, ZHANG Li-shi, GAO Huan, et al. Antipyretic Mechanism of Guizhitang and Its Effective Components Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(15): 190-197. DOI: 10.13422/j.cnki.syfjx.20181536.
Antipyretic Mechanism of Guizhitang and Its Effective Components Based on Network Pharmacology
Objective: To explore the antipyretic mechanism of Guizhitang and its effective components based on network pharmacology. Method: The structure of components in Guizhitang was predicted by ChemDraw Ultra 9.0.The targets of these components were searched by Swiss Target Prediction database. Ingenuity Pathway Analysis(IPA) software was used for seeking fever-related targets. The common pathways of components inGuizhitang and fever related targets wereanalyzed also by IPA software. The effective components were found through the Guizhitang components-target-pathway network built by Cytoscape software. Result: The Guizhitang components-target-pathway network was built. Theantipyretic effect of Guizhitang was found to be correlated with the following 6 pathways
namely G protein-coupled receptor signal
cyclic adenosine monophosphate(cAMP)-mediated signal transduction
Gαs signal
Gαi signal
adenosine 5'-monophosphate-activated protein kinase(AMPK) signal and melatonin degradation. Paeonimetabolin I and cAMP were identified as antipyretic related components in Guizhitang. Conclusion: Based on the network pharmacology
relevant pathway of theantipyretic effect of Guizhitang is discussed. Paeonimetabolin I and cAMP may be related to theantipyretic effect in the blood components of Guizhitang. However
the findings are mainly based on chemical prediction