Clinical Effect of Xuanfei Tongfu Decoction for Severe Pneumonia Combined with Gastrointestinal Dysfunction in Middle and Old Age

HAN Zheng-gui; LU Jiang-tao; WANG Wen-jing; WANG Jian

doi:10.13422/j.cnki.syfjx.20181630

您当前的位置：

首页 >

文章列表页 >

Clinical Effect of Xuanfei Tongfu Decoction for Severe Pneumonia Combined with Gastrointestinal Dysfunction in Middle and Old Age

更新时间：2024-01-04

- Clinical Effect of Xuanfei Tongfu Decoction for Severe Pneumonia Combined with Gastrointestinal Dysfunction in Middle and Old Age
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 16, Pages: 188-193(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20181630
  CLC： R57;R563.1
- Published：2018
- 稿件说明：
移动端阅览
HAN Zheng-gui, LU Jiang-tao, WANG Wen-jing, et al. Clinical Effect of Xuanfei Tongfu Decoction for Severe Pneumonia Combined with Gastrointestinal Dysfunction in Middle and Old Age[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(16): 188-193.
DOI：

HAN Zheng-gui, LU Jiang-tao, WANG Wen-jing, et al. Clinical Effect of Xuanfei Tongfu Decoction for Severe Pneumonia Combined with Gastrointestinal Dysfunction in Middle and Old Age[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(16): 188-193. DOI： 10.13422/j.cnki.syfjx.20181630.

摘要

目的：观察宣肺通腑汤治疗中老年重症肺炎合并胃肠功能障碍的疗效及对胃肠功能的保护作用及对炎症因子的影响。方法：将104例符合要求的患者随机分为对照组和观察组各52例。对照组给予抗感染治疗、抗炎治疗、对症治疗及支持治疗，给予枸橼酸莫沙必利口服溶液，10 mL/次，3次/d，口服；双歧杆菌三联活菌散，2 g/次，3次/d，口服。观察组在对照组治疗的基础上给予宣肺通腑汤，1剂/d。两组疗程均连续治疗14 d。记录治疗前后CURB65，SMART-COP，临床肺部感染评分（CPIS），中医证候评分、胃肠功能障碍（GIDF），急性病生理和长期健康Ⅱ评分（APACHEⅡ）和多器官功能障碍综合征（MODS）评分，检测治疗前后血清胃动素（MTL），胃泌素（GAS），D-乳酸，二胺氧化酶（DAO），降钙素原（PCT），白细胞介素-6（IL-6），IL-8，肿瘤坏死因子-α（TNF-α）水平；记录ICU病死率（2周内），ICU住院日、机械通气时间。结果：观察组患者临床疗效愈显率为59.62%，高于对照组愈显率38.46%（χ2=4.6564，P<0.05）；观察组机械通气时间和ICU住院日均短于对照组（P<0.01），观察组ICU病死率11.54%，低于对照组病死率15.38%，组间比较差异无统计学意义；观察组患者CURB65，SMART-COP，CPIS，中医证候，GIDF，APACHEⅡ和MODS评分均低于对照组（P<0.01）；观察组血清GAS，D-乳酸和DAO水平均低于对照组，MTL水平高于对照组（P<0.01）；观察组患者血清PCT，TNF-α，IL-6和IL-8水平均低于对照组（P<0.01）。结论：在西医常规治疗的基础上，宣肺通腑汤辅助治疗重症肺炎合并GIDF患者，可控制临床症状，调节胃肠激素，促进肠黏膜屏障修复和胃肠功能恢复，抑制炎症反应，减轻病情程度，缩短了疾病的愈合时间。

Abstract

Objective: To observe the effect of Xuanfei Tongfu decoction on severe pneumonia combined with gastrointestinal dysfunction in middle and old age

and investigate its protection effect on gastrointestinal function and inflammatory factors. Method: One hundred and four eligible patients were randomly divided into control group (52 cases) and observation group (52 cases) by random number table. Patients in control group got anti-infection treatment

anti-inflammation treatment

symptomatic treatment and supportive treatment

and they got mosapride citrate oral solution

10 mL/time

3 times/days

lactobacillus and enterococcus powder

2 g/time

3 times/days. Based on the treatment in control group

the patients in observation group additionally got Jiawei Xuanfei Tongfu decoction

1 dose/day. The treatment course was 14 days in both groups. Before and after treatment

CURB65

SMART-COP and clinical pulmonary infection score (CPIS)

scores of traditional Chinese medicine(TCM)

gastrointestinal dysfunction (GIDF)

acute physiology and chronic health evaluationⅡ score (APACHEⅡ) and scores of multiple organ dysfunction syndrome (MODS) were graded

and levels of serum motilin (MTL)

gastrin (GAS)

D-lactic acid

diamine oxidase (DAO)

procalcitonin (PCT)

interleukins-6 (IL-6)

IL-8 and tumor necrosis factor-α (TNF-α) were detected. In addition

the fatality rate in ICU (within 2 weeks)

duration of hospitalization in ICU and time of mechanical ventilation were recorded. Result: The markedly effective rate was 59.62% in observation group

higher than 38.46% in control group (χ2=4.656 4

P<0.05). The duration of hospitalization in ICU and time of mechanical ventilation in observation group were shorter than those in control group (P<0.01). The fatality rate in ICU was 11.54% in observation group

lower than 15.38% in control group

with no statistically significant differences between two groups. The scores of CURB65

SMART-COP

CPIS

TCM

GIDF

APACHEⅡ

and MODS in observation group were lower than those in control group (P<0.01). The serum GAS

D-lactic acid and DAO levels were lower while level of MTL was higher than those in control group (P<0.01). The serum PCT

TNF-α

IL-6 and IL-8 levels in observation group were lower than those in control group (P<0.01). Conclusion: Adjuvant therapy of Jiawei Xuanfei Tongfu decoction based on routine western treatment can control clinical symptoms

regulate gastrointestinal hormones

promote repair of intestinal mucosal barrier and recovery of gastrointestinal function

inhibit inflammatory reaction

relieve degree of disease and can shorten healing time in treatment for patients with severe pneumonia combined with GIDF.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Rhei Radix et Rhizoma Before and After Steaming with Wine on Intestinal Flora and Immune Environment in Constipation Model Mice

Clinical Observation on Addition and Subtraction Therapy of Huaganjian Combined with Jinlingzisan in Patients with Bile Reflux Gastritis with Stagnancy Heat of Liver and Stomach Syndrome

Effect of Rhei Radix et Rhizoma on Gastrointestinal Function of Normal Rats Before and After Simmering

Clinical Efficacy of Early Application of Da Xianxiongtang in Mitigating Progression of Acute Pancreatitis

Related Author

BAI Yaya

TIAN Rui

SHI Yajun

ZHAO Chongbo

SUN Jing

ZHANG Li

YAN Yonggang

TANG Yuping

Related Institution

Shaanxi Engineering Technology Research Center of Chinese Herbal Pieces，Shaanxi Qinling Application Development and Engineering Research Center of Chinese Herbal Medicine，Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine（TCM） for TCM Compatibility， Shaanxi University of Chinese Medicine，Xi′an

Hanlin College，Nanjing University of Chinese Medicine

Affiliated Hospital of Gansu University of Traditional Chinese Medicine

The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army

Lanzhou University Second Hospital

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰