The process that extracellular signal stimulates cell

triggering interactions among a variety of signal molecules is called cell signal transduction which finally plays its specific biological functions in human body. All kinds of intracellular and extracellular signal molecules regulate the activities of ion channels

metabolic enzymes

transcription factors and so on through the signal transduction in cells

being involved in the various aspects of diseases occurrence and development. With the further development of molecular biology

a lot of experimental researches gradually improve our understanding on the mechanism of tumor and the signal pathways involved in regulating cell proliferation

differentiation

angiogenesis

invasion and metastasis. Dysregulation of signaling pathways in the cell which eventually leads to the abnormality of cell proliferation and apoptosis

is one of the main mechanisms of cell carcinogenesis. Molecular targeted treatment for these important signaling pathways can reverse

delay and prevent carcinogenic process. As we can see in a large number of clinical practices

traditional Chinese medicine(TCM) have shown following efficacy advantages in the treatment of tumors:reducing the side effects of radiotherapy and chemotherapy

improving clinical symptoms

increasing life quality

stabilizing the tumor

preventing tumor recurrence and metastasis after operation

prolonging the survival time and improving the survival rate. What's more

lots of experimental studies have proved that some anti-tumor TCMs play a significant role in the prevention and treatment of tumor by regulating cell signal transduction in multiple pathways. In this review

based on the related experiments of Chinese medicine in recent years

we searched the related articles and summarized 11 kinds of signaling pathways involved in these researches of anti-tumor TCM

in order to provide a reference for further research.