Objective: To observe the clinical efficacy of Kuandonghua San for the treatment of acute exacerbation of bronchiectasis with the phlegm-heat stagnation syndrome.Method: A total of 100 eligible patients were randomly divided into treatment group and control group through random number table

50 cases in each group. The patients in treatment group were treated with conventional western medicine and oral Kuandonghua San

while the patients in control group were only treated with conventional western medicine. The treatment was seven days in both groups.Clinical symptom and sign scores

curative effect of traditional Chinese medicine (TCM) syndrome

blood inflammatory markers

blood gas analysis and adverse drug reactions were evaluated and compared between two groups.Result: As compared with the conditions before treatment

clinical symptom and sign scores (degree of cough

sputum volume

sputum color

sputum nature

degree of thirst

degree of constipation and degree of urine color) were decreased significantly after treatment in both groups

and those scores in treatment group were significantly lower than those in the control group (P<0.01). The total effective rate was 92% in treatment group

higher than 80% in control group (P<0.01). As compared with the levels before treatment

the levels of blood inflammatory markers (white blood cell count

neutrophil count

neutrophil to lymphocyte ratio

erythrocyte sedimentation rate

rapid C reactive protein

and procalcitonin) were significantly decreased after treatment in both groups

and the levels in treatment group were lower than those in the control group (P<0.01). In addition

both groups showed improvement in blood-gas analysis (the partial pressure of oxygen and partial pressure of carbon dioxide) after treatment in both groups

and the effect was more obvious in treatment (P<0.01). Mild diarrhea occurred in two patients of the treatment group

but was completely recovered after proper medical treatment

without affecting the subsequent treatment.Conclusion: Conventional western medicine combined with Kuandonghua San can significantly improve the clinical symptoms of patients

increase the the total effective rate

reduce the levels of blood inflammatory markers

and improve blood-gas analysis parameters. It may be an effective treatment for patients with acute exacerbation of bronchiectasis with the phlegm-heat stagnation syndrome

which is worthy of clinical popularization and application.