Chlorogenic acid is a kind of styrene acrylic analogues synthesized through photosynthesis

with high content in many kinds of Chinese medicinal materials as the main pharmacological active ingredient. Due to its extensive pharmacological effect

it is widely used in areas such as food

medicine and chemical industry. The molecular structure contains ester bond and unsaturated double bond

and other unstable structures

easy to oxidation

and it will lose its activity under light and heating conditions

but it is stable in acidic environment. It has anticancer

hypolipidemic

antioxidant

hypoglycemic

ultraviolet and radiation resistant

antibacterial

immune regulation and other functions. With the progress of science and technology and the deepening of the research

more focus has been put on anti-tumor activity. Chlorogenic acid has anti-tumor effect

showing better prevention and treatment effect on lung cancer

liver cancer

breast cancer

nasopharyngeal carcinoma

colon cancer

cervical cancer

stomach cancer

oral cancer

leukemia

retinoblastoma

melanoma

skin cancer and other tumors with higher incidence. The mechanism of chlorogenic acid may be related to blocking cell growth cycle

inhibiting tumor cell proliferation

inducing tumor cell apoptosis and inhibiting tumor angiogenesis

inhibiting metastasis

inhibiting telomerase activity

immune regulation

reversing multi-drug resistance of tumor cells

and so on. By taking chlorogenic acid

antitumor

etc as keywords

we searched related papers in Pubmed

VIP

CNKI and other databases between January 1999 and January 2018

and more than 110 related documents were obtained

but only 51 of them were effective. We reviewed the anti-tumor function and mechanism in effective papers

hoping to provide the reference for the deep research of anti-tumor activity of Chlorogenic acid.