With the change of people's life style and the improvement of living quality

hyperlipidemia has become a common clinical disease. At present

the treatment of hyperlipidemia is mainly based on drug therapy. As compared with western medicine

the mechanism of traditional Chinese medicine(TCM) for treating hyperlipidemia is complicated

but the adverse reactions are fewer. In order to explore its pathological pathogenesis

find prevention and treatment measures

and elucidate the advantages and features of TCM in treating hyperlipidemia

we need to establish an animal model that is similar to human hyperlipidemia. The animal model is the basis for experimental research

so the establishment of the animal model should be consistent with the development of the disease process

and the assessment indicators of the animal model should also correspond to the clinical indicators as far as possible. The ideal hyperlipidemia model should have the characteristics of repeatability

simple operation

low cost

and easy promotion. At present

there are many research methods for animal models of hyperlipidemia

and chemical induction is the most commonly used method. The experimental animals mainly include rats and mice

while the congenital models and transgenic models are rarely used. The biological characteristics of different animals are different

so their modeling methods are also different. According to the experimental objectives

period

techniques and other factors

selecting the right model animal and modeling method are the key to the success of hyperlipidemia experiments. This paper would summarize the recent experimental studies of hyperlipidemia animal models both at home and abroad in terms of animal selection

modeling methods and evaluation indicators of model

which will provide reference and basis for the hypolipidemic developers to study

choose and establish hyperlipidemia animal models.