Hepatic fibrosis is a repair response to various chronic liver injuries.It is also a common pathological process of various chronic liver diseases.The excessive deposition of extracellular matrix and activation of hepatic stellate cells(HSCs) are currently considered to be the main factors in the complex pathogenesis of hepatic fibrosis.Thus

anti-hepatic fibrosis has become one of the focuses on treatment research of chronic liver diseases.Xiayuxue Tang was first recorded in the book of Jinkui Yaolue (Synopsis of the Golden Chamber)

and was consisted of three Chinese medicinal herbs

Rhei Radix et Rhizoma

Persicae Semen

and Eupolyphaga Steleophaga.It has good clinical efficacy in the treatment of hepatic fibrosis and cirrhosis.This article was reviewed the study on the pharmacological effect and mechanism of anti-hepatic fibrosis of Xiayuxue Tang in recent years.It was found that Xiayuxue Tang exerts anti-hepatic fibrosis by inhibiting the activation of HSCs and inducing the apoptosis of activated HSCs

regulating the function of macrophage

inhibiting the capillarization of hepatic sinusoids and inhibiting the level of lipid peroxidation.And this article will help to the new drugs development and clinical treatment of Xiayuxue Tang in liver fibrosis.